Evidence map›Paper›PMID 32855767›Full record

ArticleOxidative medicine and cellular longevity2020

Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin

Qi Sun, Yukui Shang, Fengkai Sun, Xiwen Dong, Jun Niu, Fanni Li

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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  15. Senescent Secretome of Blind Mole RatInternational journal of molecular sciences · 2023
    Article
  16. Functional Plasmon-Activated Water IncreasesInternational journal of molecular sciences · 2022
    Article
  17. Review
  18. Article
  19. Metastasis and MAPK Pathways.International journal of molecular sciences · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Qi SunDepartment of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID https://orcid.org/0000-0001-5576-580X
Yukui ShangDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID https://orcid.org/0000-0001-7829-5396
Fengkai SunDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.ORCID https://orcid.org/0000-0003-1492-3474
Xiwen DongDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, China.ORCID https://orcid.org/0000-0003-2088-6075
Jun NiuDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.ORCID https://orcid.org/0000-0003-2588-5936
Fanni LiDepartment of Talent Highland, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID https://orcid.org/0000-0003-3573-0700
First Affiliated Hospital of Xi'an Jiaotong University · CNQilu Hospital of Shandong University · CNShandong Provincial Hospital · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The metastatic potential of colorectal cancer (CRC) is intensively promoted by the tumor microenvironment (TME) in a paracrine manner. As a pleiotropic inflammatory cytokine, Interleukin-6 (IL-6) is produced and involved in CRC, the same scenario where integrin

Indexed as

Epithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticUp-RegulationCell Line, TumorColorectal NeoplasmsFemaleFibroblastsHumansIntegrin beta ChainsInterleukin-6MaleMiddle AgedNeoplasm InvasivenessReceptors, Interleukin-6Signal TransductionSTAT3 Transcription Factorintegrin beta6Integrin beta ChainsInterleukin-6Receptors, Interleukin-6STAT3 Transcription Factor

Identifiers

PMID32855767
PMCPMC7443035
OpenAlexW3048922615

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.