Evidence map›Paper›PMID 32856709›Full record

Trial reportAmerican journal of hypertension2021

The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial.

Christine Y Bakhoum, Cheryl A M Anderson, Stephen P Juraschek, Casey M Rebholz, Lawrence J Appel, Edgar R Miller, Chirag R Parikh, Wassim Obeid, Dena E Rifkin, Joachim H Ix and 1 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06363097 (The Effect of Dietary Sodium Intake on Ambulatory Blood Pressure Levels According to Urinary Uromodulin Levels in Patients With Chronic Kidney Disease), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06363097 completednot on this mapstarted 2023, after this paper: background citation

The Effect of Dietary Sodium Intake on Ambulatory Blood Pressure Levels According to Urinary Uromodulin Levels in Patients With Chronic Kidney Disease

TypeobservationalSponsorAristotle University Of ThessalonikiRan2023 to 2025Enrolled130ConditionsChronic Kidney Disease, Hypertension
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Insights into Uromodulin and Blood Pressure.Current hypertension reports · 2024
    Review
  3. Perspectives on the involvement of the gut microbiota in salt-sensitive hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  4. Uromodulin biology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  5. Role of Uromodulin in Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Christine Y BakhoumDepartment of Pediatrics, The University of California San Diego, La Jolla, California, USA.
Cheryl A M AndersonDepartment of Family Medicine and Public Health, University of California San Diego, San Diego, California, USA.
Stephen P JuraschekDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Casey M RebholzDepartment of Epidemiology, John Hopkins University, Baltimore, Maryland, USA.
Lawrence J AppelDepartment of Epidemiology, John Hopkins University, Baltimore, Maryland, USA.
Edgar R MillerDepartment of Epidemiology, John Hopkins University, Baltimore, Maryland, USA.
Chirag R ParikhDepartment of Epidemiology, John Hopkins University, Baltimore, Maryland, USA.
Wassim ObeidDivision of Nephrology, John Hopkins University, Baltimore, Maryland, USA.
Dena E RifkinDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Joachim H IxDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California, USA.
Pranav S GarimellaDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, California, USA.
University of California San Diego · USJohns Hopkins University · USBeth Israel Deaconess Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Adult and Pediatric Nephrology Clinical Investigation Training ProgramT32DK104717 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IX, JOACHIM H · 2016 to 2020
$1.3M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
Tubular secretion, kidney disease progression, and drug dosing in older adultsK23DK114556 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARIMELLA, PRANAV · 2018 to 2022
$1.0M
The Effects of the DASH Diet and Sodium Reduction on Subclinical Cardiac DamageR21HL144876 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2018 to 2019
$263k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL135273NHLBI NIH HHS R21 HL144876NIDDK NIH HHS K23 DK114556NIDDK NIH HHS P30 DK072488NIDDK NIH HHS T32 DK104717
6 · The paper itself

Abstract

backgroundUromodulin modulates the sodium-potassium-two-chloride transporter in the thick ascending limb of the loop of Henle, and its overexpression in murine models leads to salt-induced hypertension. We hypothesized that individuals with higher baseline levels of urine uromodulin would have a greater increase in systolic blood pressure (SBP) for the same increase in sodium compared with those with lower uromodulin levels.

methodsWe used data from 157 subjects randomized to the control diet of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial who were assigned to 30 days of low (1,500 mg/d), medium (2,400 mg/d), and high salt (3,300 mg/d) diets in random order. Blood pressure was measured prerandomization and then weekly during each feeding period. We evaluated the association of prerandomization urine uromodulin with change in SBP between diets, as measured at the end of each feeding period, using multivariable linear regression.

resultsBaseline urine uromodulin stratified by tertiles was ≤17.64, 17.65-31.97, and ≥31.98 µg/ml. Across the tertiles, there were no significant differences in SBP at baseline, nor was there a differential effect of sodium diet on SBP across tertiles (low to high, P = 0.81). After adjusting for age, sex, body mass index, and race, uromodulin levels were not significantly associated with SBP change from low to high sodium diet (P = 0.42).

conclusionsIn a randomized trial of different levels of salt intake, higher urine uromodulin levels were not associated with a greater increase in blood pressure in response to high salt intake.

Indexed as

Blood PressureUromodulinAnimalsDietary Approaches To Stop HypertensionHumansHypertensionMiceSodium Chloride, DietarySodium Chloride, DietaryUromodulinblood pressureDASHhypertensionsalt sensitivitysodiumuromodulin

Identifiers

PMID32856709
PMCPMC7951043
OpenAlexW3081824221

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.