Evidence map›Paper›PMID 32860010›Full record

SynthesisProstate cancer and prostatic diseases2021

The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy: a systematic review and meta-analysis.

Ashley Bigaran, Eva Zopf, Jason Gardner, Andre La Gerche, Declan G Murphy, Erin J Howden, Michael K Baker, Prue Cormie

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Prostate cancer and prostatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07572760 (Low to Moderate Load Power Training as an Exercise Intervention for Men With Metastatic Prostate Cancer Undergoing Androgen Deprivation Therapy.), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07572760 narecruitingnot on this mapstarted 2024, after this paper: background citation

Low to Moderate Load Power Training as an Exercise Intervention for Men With Metastatic Prostate Cancer Undergoing Androgen Deprivation Therapy.

TypeinterventionalSponsorUniversity of AlicanteRan2024 to 2026Enrolled66ConditionsProstatic NeoplasmsArmsPower training group
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  3. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  6. Factors predicting gains in moderate-to-vigorous physical activity in prostate cancer survivors on androgen deprivation therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Ashley BigaranMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia. ashley.bigaran@acu.edu.au.ORCID http://orcid.org/0000-0001-6200-9244
Eva ZopfMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
Jason GardnerSchool of Exercise and Nutrition Sciences, Deakin University, Melbourne, Victoria, Australia.
Andre La GercheDepartment of Sports Cardiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Declan G MurphyDivision of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-7500-5899
Erin J HowdenDepartment of Sports Cardiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Michael K BakerSchool of Behavioural and Health Sciences, Australian Catholic University, Sydney, New South Wales, Australia.
Prue CormieMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
Australian Catholic University · AUBaker Heart and Diabetes Institute · AUDeakin University · AUPeter MacCallum Cancer Centre · AUSt. Vincent's Birmingham · USThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowing evidence suggests that men exposed to androgen deprivation therapy (ADT) have an increased risk of cardiovascular disease. While exercise has shown to attenuate some adverse effects of ADT, the effects on cardiometabolic health have not been systematically evaluated.

objectiveTo evaluate the effect of exercise on cardiometabolic health in men with prostate cancer (PCa) receiving ADT.

methodsA systematic literature search of MEDLINE, EMBASE, CINHAL, SCOPUS, WEB OF SCIENCE and SPORTSDICUS from database inception to April 2020 was performed. A quantitative synthesis using Cohens d effect size and a meta-analysis using random-effects models were conducted.

resultsOverall, fourteen randomised controlled trials (RCTs) and four non-randomised studies were included. Eleven RCTs (n = 939 patients) were included in the meta-analysis. Exercise training improved the 400-m-walk test (MD -10.11 s, 95% CI [-14.34, -5.88]; p < 0·00001), diastolic blood pressure (-2.22 mmHg, [-3.82, -0.61]; p = 0.007), fasting blood glucose (-0.38 mmol/L, [-0.65, -0.11]; p = 0.006), C-reactive protein (-1.16 mg/L, [-2.11, -0.20]; p = 0.02), whole-body lean mass (0.70 kg, [0.39, 1.01]; p < 0.0001), appendicular lean mass (0.59 kg, [0.43, 0.76]; p < 0.00001), whole-body fat mass (-0.67 kg, [-1.08, -0.27]; p = 0.001), whole-body fat percentage (-0.79%, [-1.16, -0.42]; p < 0.0001), and trunk fat mass (-0.49 kg, [-0.87, -0.12]; p = 0.01), compared to usual care. No significant effects on systolic blood pressure or blood lipid metabolism were detected.

conclusionsIn a small subset of evaluated studies, exercise may favourably improve some but not all markers of cardiometabolic health. Future exercise intervention trials with cardiometabolic outcomes as primary endpoints are needed to confirm these initial findings.

Indexed as

Androgen AntagonistsAntineoplastic Agents, HormonalCardiovascular DiseasesExerciseExercise TherapyGlobal HealthHormone Replacement TherapyHumansIncidenceMaleProstatic NeoplasmsQuality of LifeAndrogen AntagonistsAntineoplastic Agents, Hormonal

Identifiers

PMID32860010
OpenAlexW3081600027

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.