Evidence map›Paper›PMID 32860770›Full record

ArticleMicrovascular research2020

Improved conjunctival microcirculation in diabetic retinopathy patients with MTHFR polymorphisms after Ocufolin™ Administration.

Zhiping Liu, Hong Jiang, Justin H Townsend, Jianhua Wang

Open access · hybridAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Microvascular research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Effects of Methylenetetrahydrofolate Reductase (Clinical ophthalmology (Auckland, N.Z.) · 2023
    Article
  5. Article
  6. Treatment of Glaucoma Patients with Flammer Syndrome.Journal of clinical medicine · 2021
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Zhiping LiuOphthalmic Center, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, USA.
Hong JiangDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, USA; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Justin H TownsendDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, USA.
Jianhua WangDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, USA. Electronic address: jwang3@med.miami.edu.
University of Miami · USGuangzhou Medical University · CN

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Novel Biomarkers of Small Vessel Contributions to Vascular Cognitive Impairment and Dementia (VCID)R01NS111115 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A, WANG, JIANHUA · 2019 to 2023
$3.7M
NEI NIH HHS P30 EY014801NINDS NIH HHS R01 NS111115
6 · The paper itself

Abstract

purposeTo investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg l-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic acid, calcium salt), methylcobalamin, and other ingredients.

methodsEight D + PM patients received Ocufolin™ for six months (6 M). Bulbar conjunctival microvasculature and microcirculation metrics, including vessel diameter (D), axial blood flow velocity (Va), cross-sectional blood flow velocity (Vs), flow rate (Q), and vessel density (VD, Dbox), were measured at baseline, 4 M, and 6 M.

resultsThe mean age was 54 ± 7 years. No significant demographic differences were found. Conjunctival microcirculation, measured as Va, Vs, and Q was significantly increased at 4 M and 6 M, compared to baseline. Va was 0.44 ± 0.10 mm/s, 0.58 ± 0.13 mm/s, 0.59 ± 0.13 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.01). Similarly, Vs was 0.31 ± 0.07 mm/s, 0.40 ± 0.09 mm/s, 0.41 ± 0.09 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). Q was 107.8 ± 49.4 pl/s, 178.0 ± 125.8 pl/s, 163.3 ± 85.8 mm/s in baseline, 4 M, and 6 M, respectively (P < 0.05). The VD at 6 M was significantly higher than that at baseline (P = 0.017). Changes of D were positively correlated with changes of Va, Q, and VD. Effects of MTHFR and haptoglobin polymorphisms on the improvements of conjunctival microcirculation and microvasculature were found.

conclusionsOcufolin™ supplementation improves conjunctival microcirculation in patients with diabetic retinopathy and common folate polymorphisms.

Indexed as

Dietary SupplementsPolymorphism, Single NucleotideAgedBlood Flow VelocityConjunctivaDiabetic RetinopathyFemaleHumansMaleMethylenetetrahydrofolate Reductase (NADPH2)MicrocirculationMiddle AgedProspective StudiesRecovery of FunctionRegional Blood FlowTime FactorsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanOcufolinConjunctival microcirculationConjunctival microvasculatureDiabetes mellitusDiabetic retinopathyFunctional slit-lamp biomicroscopyHaptoglobinl-methylfolateMedical foodMTHFR

Identifiers

PMID32860770
PMCPMC7572694
OpenAlexW3081924229

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.