Evidence map›Paper›PMID 32862701›Full record

ArticleHuman gene therapy2020

Transduction of Surface and Basal Cells in Rhesus Macaque Lung Following Repeat Dosing with AAV1CFTR.

William B Guggino, Murali K Yanda, Cristina V Cebotaru, Liudmila Cebotaru

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human gene therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cas-Based Systems for RNA Editing in Gene Therapy of Monogenic Diseases:Frontiers in cell and developmental biology · 2022
    Review
  6. Tissue and cell-type-specific transduction using rAAV vectors in lung diseases.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

William B GugginoDepartments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Murali K YandaDepartments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cristina V CebotaruDepartments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Liudmila CebotaruDepartments of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · US

Funding

CF Gene Therapy with adeno-associated viral vectorsR01HL122267 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CEBOTARU, LIUDMILA, GUGGINO, WILLIAM B. · 2016 to 2020
$3.4M
LSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439k
NHLBI NIH HHS R01 HL122267NIH HHS S10 OD023548
6 · The paper itself

Abstract

To test the effectiveness of repeat dosing, we sprayed two doses (10

Indexed as

Transduction, GeneticAnimalsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDependovirusDose-Response Relationship, DrugGenetic TherapyGenetic VectorsGene Transfer TechniquesGenome, ViralHumansLungMacaca mulattaCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorAAV1basal cellsCFTRcystic fibrosislungrepeat dosingrhesussurface cells

Identifiers

PMID32862701
PMCPMC7495919
OpenAlexW3081639909

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.