Evidence map›Paper›PMID 32864621›Full record

ArticleFunction (Oxford, England)2020

Fusion-Independent Satellite Cell Communication to Muscle Fibers During Load-Induced Hypertrophy.

Kevin A Murach, Ivan J Vechetti, Douglas W Van Pelt, Samuel E Crow, Cory M Dungan, Vandre C Figueiredo, Kate Kosmac, Xu Fu, Christopher I Richards, Christopher S Fry and 2 more

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 87 citations in OpenAlex.

  1. Trial
  2. Article
  3. Myonuclear Dynamics After Skeletal Muscle Surgical Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Article
  5. Review
  6. Myonuclear Dynamics After Skeletal Muscle Surgical Injury.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Making sense of MYC in skeletal muscle: location, duration, and magnitude.American journal of physiology. Cell physiology · 2025
    Article
  18. Review
  19. Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Kevin A MurachThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-2783-7137
Ivan J VechettiThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Douglas W Van PeltThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Samuel E CrowThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Cory M DunganThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Vandre C FigueiredoThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Kate KosmacThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Xu FuDepartment of Chemistry, College of Arts and Sciences, University of Kentucky, Lexington, KY 40536, USA.
Christopher I RichardsDepartment of Chemistry, College of Arts and Sciences, University of Kentucky, Lexington, KY 40536, USA.
Christopher S FryThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
John J McCarthyThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
Charlotte A PetersonThe Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA.
University of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
The role of satellite cells in adult skeletal muscle growth and maintenanceR01AR060701 · NIAMS · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2010 to 2019
$3.3M
Exercise-induced skeletal muscle exosomes promote adipocyte lipolysisR01DK119619 · NIDDK · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2018 to 2022
$2.3M
The effects of exercise on satellite cell dynamics during agingR01AG049806 · NIA · UNIVERSITY OF KENTUCKY · PI MCCARTHY, JOHN JOSEPH, PETERSON, CHARLOTTE A. · 2016 to 2020
$1.8M
Myonuclear Epigenetics of Skeletal Muscle Mass Regulation with AgeR00AG063994 · NIA · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MURACH, KEVIN · 2021 to 2023
$735k
Myonuclear Epigenetics of Skeletal Muscle Mass Regulation with AgeK99AG063994 · NIA · UNIVERSITY OF KENTUCKY · PI MURACH, KEVIN · 2019 to 2020
$197k
Fusion-Independent Roles of Satellite Cells in Muscle AdaptationF32AR071753 · NIAMS · UNIVERSITY OF KENTUCKY · PI MURACH, KEVIN · 2017 to 2019
$184k
NCI NIH HHS P30 CA177558NIAMS NIH HHS F32 AR071753NIAMS NIH HHS R01 AR060701NIA NIH HHS K99 AG063994NIA NIH HHS R00 AG063994NIA NIH HHS R01 AG049806NIDDK NIH HHS R01 DK119619
6 · The paper itself

Abstract

The "canonical" function of Pax7+ muscle stem cells (satellite cells) during hypertrophic growth of adult muscle fibers is myonuclear donation via fusion to support increased transcriptional output. In recent years, however, emerging evidence suggests that satellite cells play an important secretory role in promoting load-mediated growth. Utilizing genetically modified mouse models of delayed satellite cell fusion and

Indexed as

Extracellular MatrixMuscle Fibers, SkeletalAnimalsCell CommunicationDisease Models, AnimalHypertrophyMiceextracellular vesiclesmiRNAMmp9Nr4a1Pax7-DTAtdTomato

Identifiers

PMID32864621
PMCPMC7448100
OpenAlexW3038607983

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.