ArticleNature communications2020
An orphan protein of Fusarium graminearum modulates host immunity by mediating proteasomal degradation of TaSnRK1α.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 170 citations in OpenAlex.
- Priority actions for Fusarium head blight resistance in durum wheat: Insights from the wheat initiative.The plant genome · 2025Pooled it
- Review
- Infection mechanisms ofiMeta · 2026Article
- The MdERF1B-miR482c-Horticulture research · 2026Article
- A conserved fungal Egh16-like effector suppresses host defense by disrupting ATP binding of wheat MPK3.Journal of integrative plant biology · 2026Article
- Multiplexed Engineering of Disease Resistance and Lodging Tolerance in Wheat Via a Single Xylan Modifying Glycosyltransferase.Plant biotechnology journal · 2026Article
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- Nuclear SnRK1 Activity Delays Clubroot Development in Arabidopsis by Reducing Sink Strength.Plant, cell & environment · 2026Article
- Effector FpECIR from Fusarium pseudograminearum targets wheat ethylene signaling pathway to suppress plant immunity.Stress biology · 2026Article
- A new plant SUMO ligase, MPEL1, synergizes with MAPK16 to regulate resistance against Fusarium pathogens.The EMBO journal · 2026Article
- Integrated taxonomy and genomic analysis of Marssonina zanthoxyli, the causal agent of prickly ash leaf defoliation.BMC genomics · 2026Article
- Vacuolar iron transporters mediate resistance to triadimefon in plant pathogenic fungi.Nature communications · 2026Article
- H3K27me3-Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion.Plant biotechnology journal · 2026Article
- Article
- Polarisome core component FgPea2 regulates FgBoi2-mediated polarized growth, pathogenicity and environmental stress in Fusarium graminearum.Stress biology · 2026Article
- Ustilago maydis disrupts carbohydrate signaling networks to induce hypertrophy in host cells.Nature communications · 2026Article
- Exploitation of Host-Derived N-Feruloylputrescine by Fusarium graminearum Promotes DON Biosynthesis and Wheat Rachis Colonisation.Molecular plant pathology · 2026Article
- The phenol-2-monooxygenase FgPhm1 regulates DON synthesis, pathogenicity and environmental stress response inVirulence · 2025Article
- Orphan and de novo Genes in Fungi and Animals: Identification, Origins and Functions.Genome biology and evolution · 2025Review
- FgNdk1 Promotes Effector Secretion to Scavenge ROS During Fusarium graminearum Infection.Molecular plant pathology · 2025Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium graminearum is a causal agent of Fusarium head blight (FHB) and a deoxynivalenol (DON) producer. In this study, OSP24 is identified as an important virulence factor in systematic characterization of the 50 orphan secreted protein (OSP) genes of F. graminearum. Although dispensable for growth and initial penetration, OSP24 is important for infectious growth in wheat rachis tissues. OSP24 is specifically expressed during pathogenesis and its transient expression suppresses BAX- or INF1-induced cell death. Osp24 is translocated into plant cells and two of its 8 cysteine-residues are required for its function. Wheat SNF1-related kinase TaSnRK1α is identified as an Osp24-interacting protein and shows to be important for FHB resistance in TaSnRK1α-overexpressing or silencing transgenic plants. Osp24 accelerates the degradation of TaSnRK1α by facilitating its association with the ubiquitin-26S proteasome. Interestingly, TaSnRK1α also interacts with TaFROG, an orphan wheat protein induced by DON. TaFROG competes against Osp24 for binding with the same region of TaSnRKα and protects it from degradation. Overexpression of TaFROG stabilizes TaSnRK1α and increases FHB resistance. Taken together, Osp24 functions as a cytoplasmic effector by competing against TaFROG for binding with TaSnRK1α, demonstrating the counteracting roles of orphan proteins of both host and fungal pathogens during their interactions.
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