Evidence map›Paper›PMID 32876940›Full record

ReviewJournal of nephrology2021

Sarcopenia in chronic kidney disease: what have we learned so far?

Alice Sabatino, Lilian Cuppari, Peter Stenvinkel, Bengt Lindholm, Carla Maria Avesani

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07151742 (Investigation of the Effects of Intradialytic Combined Exercises on Dialysis Parameters and Muscle Oxygenation in Sarcopenic Hemodialysis Patients), which is not on this map. Cited by 281 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed, 9 pooled it
30.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07151742 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Investigation of the Effects of Intradialytic Combined Exercises on Dialysis Parameters and Muscle Oxygenation in Sarcopenic Hemodialysis Patients

TypeinterventionalSponsorIstinye UniversityRan2025 to 2025Enrolled40ConditionsChronic Kidney Disease, Stage 5, SarcopeniaArmsEXERCISE TRAINING WITH OR WITHOUT MEDICATION
3 · Its place in the literature

Who cites it

281 citing papers in PubMed, 9 syntheses or guidelines pooled it, 476 citations in OpenAlex.

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221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Alice SabatinoDivision of Nephrology, Department of Medicine and Surgery, University of Parma, Parma, Italy.ORCID http://orcid.org/0000-0003-2098-7597
Lilian CuppariDivision of Nephrology, Federal University of São Paulo and Oswaldo Ramos Foundation, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-5927-9179
Peter StenvinkelDivision of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8785-4820
Bengt LindholmDivision of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4269-4293
Carla Maria AvesaniDivision of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institute, Stockholm, Sweden. carla.avesani@ki.se.ORCID http://orcid.org/0000-0002-4458-8358
Karolinska Institutet · SEUniversidade Federal de São Paulo · BRUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of muscle loss that occurs in the elderly. Since then, a broader definition comprising not only loss of muscle mass, but also loss of muscle strength and low physical performance due to ageing or other conditions, was developed and published in consensus papers from geriatric societies. Sarcopenia was proposed to be diagnosed based on operational criteria using two components of muscle abnormalities, low muscle mass and low muscle function. This brought awareness of an important nutritional derangement with adverse outcomes for the overall health. In parallel, many studies in patients with chronic kidney disease (CKD) have shown that sarcopenia is a prevalent condition, mainly among patients with end stage kidney disease (ESKD) on hemodialysis (HD). In CKD, sarcopenia is not necessarily age-related as it occurs as a result of the accelerated protein catabolism from the disease and from the dialysis procedure per se combined with low energy and protein intakes. Observational studies showed that sarcopenia and especially low muscle strength is associated with worse clinical outcomes, including worse quality of life (QoL) and higher hospitalization and mortality rates. This review aims to discuss the differences in conceptual definition of sarcopenia in the elderly and in CKD, as well as to describe etiology of sarcopenia, prevalence, outcome, and interventions that attempted to reverse the loss of muscle mass, strength and mobility in CKD and ESKD patients.

Indexed as

Renal Insufficiency, ChronicSarcopeniaAgedHumansMuscle StrengthQuality of LifeRenal DialysisChronic kidney diseaseEnd stage kidney diseaseMuscle strengthPhysical performanceSarcopeniaSkeletal muscle mass

Identifiers

PMID32876940
PMCPMC8357704
OpenAlexW3082064123

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.