Evidence map›Paper›PMID 32878636›Full record

ArticleJournal of neuroinflammation2020

Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8

Benjamin R Cassidy, Miao Zhang, William E Sonntag, Douglas A Drevets

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. The neuroimmune system and cognition.Nature immunology · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Neuroimmune Consequences of L. monocytogenes Infection.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Review
  10. Oral SpirocheteInternational journal of molecular sciences · 2023
    Article
  11. Review
  12. Article
  13. Keeping T cell memories in mind.Trends in immunology · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Discipline in Stages: Regulating CD8Frontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Benjamin R CassidyDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Miao ZhangDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
William E SonntagDepartment of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Douglas A DrevetsDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. douglas-drevets@ouhsc.edu.ORCID http://orcid.org/0000-0001-7068-9251
University of Oklahoma Health Sciences Center · USUniversity of Oklahoma Medical Center · US

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
NCI NIH HHS P30 CA225520
6 · The paper itself

Abstract

backgroundBrain inflammation is a key cause of cognitive decline after central nervous system (CNS) infections. A thorough understanding of immune responses to CNS infection is essential for developing anti-inflammatory interventions that improve outcomes. Tissue-resident memory T cells (T

methodsC57BL/6J mice were infected by intraperitoneal injection with a lethal inoculum of Listeria monocytogenes (Lm) then treated with antibiotics. Flow cytometry was used to quantify specific populations of brain leukocytes 28-29 days (d) post-infection (p.i.). To test the degree to which miR-155 altered leukocyte influxes into the brain, infected mice were injected with a miR-155 inhibitor or locked nucleic acid (LNA) scramble control 2d, 4d, 6d, and 8d p.i. along with antibiotic treatment. Bacterial loads in spleen and liver and body weights were measured up to 7d p.i. Brain leukocytes were analyzed 14d and 28d p.i. Confirmatory studies were performed in mutated mice lacking miR-155 (miR-155

conclusionsBrain CD8

Indexed as

Immunologic MemoryAmpicillinAnimalsAnti-Bacterial AgentsBrainCD8-Positive T-LymphocytesCytokinesListeriosisMiceMicroRNAsAmpicillinAnti-Bacterial AgentsCytokinesMicroRNAsMirn155 microRNA, mouseListeriaMeningitismiR-155SepsisTissue-resident memory cells

Identifiers

PMID32878636
PMCPMC7466815
OpenAlexW3082892587

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.