Evidence map›Paper›PMID 32880371›Full record

SynthesiseLife2020

A connectome and analysis of the adult

Louis K Scheffer, C Shan Xu, Michal Januszewski, Zhiyuan Lu, Shin-Ya Takemura, Kenneth J Hayworth, Gary B Huang, Kazunori Shinomiya, Jeremy Maitlin-Shepard, Stuart Berg and 98 more

Abstract readSystematic Review

PubMed Full text at PMC Publisher

In one paragraph

Synthesis in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 630 papers.

0numbers the graph read from it

0cells of the map it votes in

630citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

630 citing papers in PubMed.

Elements of olfactory intelligence in Drosophila.Biological cybernetics · 2026
Article
Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep.eLife · 2026
Article
Convergent olfactory circuits for courtship in Drosophila revealed by the circuit-tracing tool ds-Tango.Current biology : CB · 2026
Article
Cell-type-specific circadian and light-responsive transcriptional dynamics in adultProceedings of the National Academy of Sciences of the United States of America · 2026
Article
Cellular and functional dissection of the octopaminergic and tyraminergic system in the Drosophila brain.Current biology : CB · 2026
Article
Recurrent synapses between CO2-sensitive olfactory sensory neurons enable robust CO2 detection in Aedes aegypti mosquitoes.PLoS biology · 2026
Article
Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026
Article
Central complex representations of self-movement are sufficient to compute wind direction in flight.Science advances · 2026
Article
Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
Article
Hunger states modulate aggression via opposing dopamine pathways.Nature communications · 2026
Article
A new bridge from sleep to wake in fruit flies.Sleep · 2026
Article
Context-dependent arousal via wake-promoting pontine neurons in the Drosophila melanogaster fan-shaped body.Sleep · 2026
Article
An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition inScience advances · 2026
Article
Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026
Article
Distributed control circuits across a brain-and-cord connectome.Nature · 2026
Article
Glial cell toxicity in a Drosophila C9orf72 neurodegeneration model.PLoS genetics · 2026
Article
An in silico framework for dissecting the mechanistic origins of in vivo recorded neuronal activity.PLoS computational biology · 2026
Article
Toward reliable machine learning models for neural circuit inference: A diagnostic study of CNNs on spike trains.PLoS computational biology · 2026
Article
Organization of circuits linking descending input to motor output in theeLife · 2026
Article
Connectome quality converges predictably to reveal optimal stopping points during proofreading.bioRxiv : the preprint server for biology · 2026
Article

570 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

Commented on by
Mapping the mind of a fly.2020

5 · Who and what money

Authors and funding

108 authors.

Louis K Scheffer *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-3289-6564

C Shan Xu *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8564-7836

Michal Januszewski *Google Research, Mountain View, United States.ORCID 0000-0002-3480-2744

Zhiyuan Lu *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-4128-9774

Shin-Ya Takemura *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-2400-6426

Kenneth J Hayworth *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Gary B Huang *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-9606-3510

Kazunori Shinomiya *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-0262-6421

Jeremy Maitlin-ShepardGoogle Research, Google LLC, Zurich, Switzerland.ORCID 0000-0001-8453-7961

Stuart BergJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Jody ClementsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Philip M HubbardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-6746-5035

William T KatzJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-9417-6212

Lowell UmayamJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Ting ZhaoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

David AckermanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-0172-6594

Tim BlakelyGoogle Research, Mountain View, United States.ORCID 0000-0003-0995-5471

John BogovicJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-4829-9457

Tom DolafiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Dagmar KainmuellerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-9830-2415

Takashi KawaseJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Khaled A KhairyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-9274-5928

Laramie LeavittGoogle Research, Mountain View, United States.

Peter H LiGoogle Research, Mountain View, United States.ORCID 0000-0001-6193-4454

Larry LindseyGoogle Research, Mountain View, United States.

Nicole NeubarthJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Donald J OlbrisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Hideo OtsunaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Eric T TrautmanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-8588-0569

Masayoshi ItoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Alexander S BatesMRC Laboratory of Molecular Biology, Cambridge, United States.ORCID 0000-0002-1195-0445

Jens GoldammerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-5623-8339

Tanya WolffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8681-1749

Robert SvirskasJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-8374-6008

Philipp SchlegelMRC Laboratory of Molecular Biology, Cambridge, United States.ORCID 0000-0002-5633-1314

Erika NeaceJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Christopher J KnechtJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-5663-5967

Chelsea X AlvaradoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-5973-7512

Dennis A BaileyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-4675-8373

Samantha BallingerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Jolanta A BoryczLife Sciences Centre, Dalhousie University, Halifax, Canada.ORCID 0000-0002-4402-9230

Brandon S CaninoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8454-865X

Natasha CheathamJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Michael CookJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-7892-6845

Marisa DreherJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-0041-9229

Octave DuclosJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Bryon EubanksJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-9288-2009

Kelli FairbanksJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-6601-4830

Samantha FinleyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8086-206X

Nora ForknallJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-2139-7599

Audrey FrancisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-1974-7174

Gary Patrick HopkinsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Emily M JoyceJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-5794-6321

SungJin KimJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Nicole A KirkJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Julie KovalyakJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-7864-7734

Shirley A LauchieJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-8223-9522

Alanna LohffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-1242-1836

Charli MaldonadoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Emily A ManleyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Sari McLinLife Sciences Centre, Dalhousie University, Halifax, Canada.ORCID 0000-0002-9120-1136

Caroline MooneyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Miatta NdamaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Omotara OgundeyiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Nneoma OkeomaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Christopher OrdishJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Nicholas PadillaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Christopher M PatrickJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-8830-1892

Tyler PatersonJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Elliott E PhillipsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-4918-2058

Emily M PhillipsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-7615-301X

Neha RampallyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Caitlin RibeiroJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Madelaine K RobertsonLife Sciences Centre, Dalhousie University, Halifax, Canada.ORCID 0000-0002-1764-0245

Jon Thomson RymerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-4271-6774

Sean M RyanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8879-6108

Megan SammonsJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-4516-5928

Anne K ScottJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Ashley L ScottJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Aya ShinomiyaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-6358-9567

Claire SmithJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Kelsey SmithJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Natalie L SmithJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8271-9873

Margaret A SobeskiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Alia SuleimanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Jackie SwiftJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-1321-8183

Satoko TakemuraJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-2863-0050

Iris TalebiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-0173-8053

Dorota TarnogorskaLife Sciences Centre, Dalhousie University, Halifax, Canada.ORCID 0000-0002-7063-6165

Emily TenshawJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Temour TokhiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

John J WalshJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-7176-4708

Tansy YangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-1131-0410

Jane Anne HorneLife Sciences Centre, Dalhousie University, Halifax, Canada.ORCID 0000-0001-9673-2692

Feng LiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Ruchi ParekhJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8060-2807

Patricia K RivlinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Vivek JayaramanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-3680-7378

Marta CostaDepartment of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-5948-3092

Gregory Sxe JefferisMRC Laboratory of Molecular Biology, Cambridge, United States.ORCID 0000-0002-0587-9355

Kei ItoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-7274-5533

Stephan SaalfeldJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-4106-1761

Reed GeorgeJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Ian A MeinertzhagenJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

Gerald M RubinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-8762-8703

Harald F HessJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-3000-1533

Viren JainGoogle Research, Google LLC, Zurich, Switzerland.

Stephen M PlazaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-7425-8555

Funding

Howard Hughes Medical Institute

6 · The paper itself

Abstract

The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly

Indexed as

AnimalsBrainConnectomeDrosophila melanogasterFemaleMaleNeuronsSynapsesbrain regionscell typescomputational biologyconnectomeconnectome reconstuction methodsD. melanogastergraph propertiesneurosciencesynapse detectonsystems biology

Identifiers

PMID32880371

DOI10.7554/eLife.57443

PMCPMC7546738

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.