Evidence map›Paper›PMID 32880800›Full record

ArticleBiological trace element research2021

Calcium Fructoborate Prevents Skin Cancer Development in Balb-c Mice: Next Part, Reverse Inflammation, and Metabolic Alteration.

Mehmet Ali Kisacam, Gonca Ozan Kocamuftuoglu, Ibrahim Enver Ozan, Mehmet Yaman, SemaTemizer Ozan

Abstract read
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In one paragraph

Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mehmet Ali KisacamDepartment of Biochemistry, Faculty of Veterinary Medicine, Mustafa Kemal University, 31060, Hatay, Turkey. mkisacam@firat.edu.tr.ORCID https://orcid.org/0000-0003-0521-9434
Gonca Ozan KocamuftuogluDepartment of Biochemistry, Faculty of Veterinary Medicine, Mehmet AkifErsoy University, 15030, Burdur, Turkey.ORCID https://orcid.org/0000-0001-6874-3669
Ibrahim Enver OzanDepartment of Histology and Embryology, Faculty of Medicine, Firat University, 23200, Elazig, Turkey.ORCID https://orcid.org/0000-0002-7274-5138
Mehmet YamanDepartment of Chemistry, Faculty of Science, Firat University, 23200, Elazig, Turkey.ORCID https://orcid.org/0000-0002-3008-2671
SemaTemizer OzanDepartment of Biochemistry, Faculty of Veterinary Medicine, Firat University, 23200, Elazig, Turkey.ORCID https://orcid.org/0000-0002-2274-1999
Fırat University · TRBurdur Mehmet Akif Ersoy Üniversitesi · TRMustafa Kemal University · TR

Funding

National Boron Institution of Turkey 2016-31-07-15-003.
6 · The paper itself

Abstract

Metabolic alterations and inflammation are regarded as hallmarks of cancer. Glycolytic flux and intermediate accumulation lead to the production of building blocks and NADPH which is important in protecting the cell from oxidative damage. Inflammation causes the release of mediators responsible for regulating molecular mechanism affecting metabolic pathways. CaFB due to its cis-diol-rich feature may have the potential to interact with molecules taking part in cancer development. This study was aimed to investigate the effects of CaFB on metabolic alterations and inflammation in 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin cancer. For this purpose, 92 Balb-c mice were distributed into 6 groups as control, CaFB, DMBA/TPA (D-T), treatment 1 (T1), 2 (T2), and 3(T3). Apart from control and CaFB in other groups, tumors initiated with 97.5-nmol DMBA and 6.5-nmol TPA. Treatment groups received 3 mg/kg/day CaFB with DMBA (T1), with TPA (T2), and after tumor formation (T3). In the D-T group, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity, 6-phosphogluconate dehydrogenase (PGD), glutathione (GSH), interleukin 6 (IL-6), (IL-1β), tumor necrosis factor-α (TNF-α) levels increased (p < 0.001) while malondialdehyde (MDA) levels decreased (p < 0.001) compared with that in control. CaFB application ameliorated DMBA-TPA effect according to the distribution time. It is noteworthy to consider CaFB as a potential preventive agent in skin cancer development.

Indexed as

9,10-Dimethyl-1,2-benzanthraceneSkin NeoplasmsAnimalsBoratesCarcinogensFructoseInflammationMiceMice, Inbred BALB CSkin9,10-Dimethyl-1,2-benzanthraceneBoratescalcium fructoborateCarcinogensFructose6-Phosphogluconate dehydrogenaseCalcium fructoborateGlyceraldehyde-3-phosphate dehydrogenaseInflammationOxidative stressSkin cancer

Identifiers

PMID32880800
OpenAlexW3083567484

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.