SynthesisJournal of hepatology2021
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 3 pooled it
11.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Meta-Analysis: Effects of Steatotic Liver Disease-Associated Genetic Risk Alleles on Longitudinal Outcomes.Alimentary pharmacology & therapeutics · 2025Pooled it
- Druggable genome-wide Mendelian randomization identifies therapeutic targets for metabolic dysfunction-associated steatotic liver disease.Lipids in health and disease · 2025Pooled it
- Genome-Wide Association Study of NAFLD Using Electronic Health Records.Hepatology communications · 2022Pooled it
- Genetics of MASLD: a diabetes perspective.Diabetologia · 2026Review
- Prime editing models the MTARC1 A165T variant in human liver organoids, demonstrating reduced steatosis, inflammation, and fibrosis.Hepatology communications · 2026Article
- European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) steatotic liver disease special interest group position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease.Journal of pediatric gastroenterology and nutrition · 2026Article
- The Emerging Challenge of Non-Cirrhotic MASLD-Related Hepatocellular Carcinoma: Etiology, Immunopathology, and Precision Oncology.Liver cancer · 2026Review
- Review
- Genetic and genomic insights across the steatotic liver disease spectrum.Clinical and molecular hepatology · 2026Review
- Article
- Review
- Beyond Fat: Reframing MASLD Through Genetics, Clonal Biology, and Precision Hepatology.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Integrating CRISPR genome editing with liver organoid and hiPSC-derived microfluidic platforms to model metabolic dysfunction-associated steatotic liver disease.Biochemistry and biophysics reports · 2026Review
- Association of Genetic Variants inInternational journal of molecular sciences · 2026Article
- Genetic and lifestyle determinants of lipid profiles in Japanese young adults: evidence from MBOAT7 rs641738.Lipids in health and disease · 2026Article
- From Cure to Complexity: Post-SVR Liver and Metabolic Trajectories in Diabetic Patients.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Mechanisms and therapeutic insights into MASH-associated fibrosis.Trends in endocrinology and metabolism: TEM · 2026Review
- Genetic modulators of metabolic dysfunction-associated steatotic liver disease (MASLD) and their epistatic interactions: from in vitro and animal models to clinical outcomes.BMC medical genomics · 2026Review
- A Global Perspective on Metabolic Dysfunction-Associated Steatotic Liver Disease: From Molecular Mechanisms to Therapeutic Strategy Innovation.Nutrients · 2026Review
- A mitochondrial amidoxime-reducing component 1 (mARC1) A168T amino acid substitution does not confer protection from MASH and fibrosis in multiple mouse models of chronic liver disease.The Biochemical journal · 2026Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
73 authors at 20 institutions in 13 countries.
Kevin TeoSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Kushala W M AbeysekeraMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Leon AdamsMedical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia; Department of Hepatology, Sir Charles Gairdner Hospital, Perth, WA, Australia.
Elmar AignerFirst Department of Medicine, Paracelsus Medical University Salzburg, Austria.
Quentin M AnsteeTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Jesus M BanalesDepartment on Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), CIBERehd, Ikerbasque, San Sebastian, Spain.
Rajarshi BanerjeePerspectum Ltd, Oxford, UK.
Priyadarshi BasuNational Institute of Biomedical Genomics, Kalyani, India.
Thomas BergDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Pallav BhatnagarEli Lilly and Company, Indianapolis, IN, USA.
Stephan BuchMedical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.
Ali CanbayGastroenterology, Hepatology and Infectiology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Sonia CaprioYale University, Department of Pediatrics, New Haven, CT, USA.
Ankita ChatterjeeNational Institute of Biomedical Genomics, Kalyani, India.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Abhijit ChowdhuryInstitute of Post Graduate Medical Education and Research, Kolkata, India.
Ann K DalyTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Christian DatzDepartment of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Austria.
Dana de Gracia HahnSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Johanna K DiStefanoDiabetes and Fibrotic Disease Unit Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.
Jiawen DongSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Amedine DuretSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
EU-PNAFLD Investigators
Connor EmdinProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Boston, MA, USA.
Madison FaireySchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Glenn S GerhardDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
GOLD Consortium
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Jochen HampeMedical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.
Matthew HickmanMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Lena HeintzDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Christian HudertDepartment of Pediatric Gastroenterology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Harriet HunterSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Matt KellyPerspectum Ltd, Oxford, UK.
Julia KozlitinaEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Marcin KrawczykDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany; Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.
Frank LammertDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Joel LavineDepartment of Pediatrics, Columbia University, New York, NY, USA.
Lin LiBioStat Solutions LLC, Frederick, MD, USA.
Hong Kai LimSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Rohit LoombaNAFLD Research Center, Division of Gastroenterology and Epidemiology, University of California at San Diego, La Jolla, CA, USA.
Panu K LuukkonenMinerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Yale University School of Medicine, New Haven, CT, USA.
Phillip E MeltonSchool of Global Population Health, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, WA, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia.
Trevor A MoriMedical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Constantinos A ParisinosInstitute of Health Informatics, Faculty of Population Health Sciences, University College London, London, UK.
Sreekumar G PillaiEli Lilly and Company, Indianapolis, IN, USA.
Faiza QayyumDepartment of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Matthias C ReichertDepartment of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.
Stefano RomeoDepartment of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Yu Ri ImSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Nicola SantoroYale University, Department of Pediatrics, New Haven, CT, USA; Department of Medicine and Health Sciences 'V. Tiberio' University of Molise, Campobasso, Italy.
Clemens SchafmayerDepartment of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany.
Elizabeth K SpeliotesDivision of Gastroenterology and Hepatology, Department of Medicine, University of Michigan Health System, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
Stefan StenderDepartment of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Felix StickelDepartment of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland.
Christopher D StillGeisinger Obesity Institute, Danville, PA, USA.
Pavel StrnadMedical Clinic III, University Hospital RWTH Aachen, Aachen, Germany.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Anne Tybjærg-HansenDepartment of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Giuseppina Rosaria UmanoYale University, Department of Pediatrics, New Haven, CT, USA; Department of the Woman, the Child, of General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy.
Mrudula UtukuriSchool of Clinical Medicine, University of Cambridge, Cambridge, UK.
Luca ValentiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy.
Lynne E WagenknechtDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Richard M WatanabeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Julia WattacherilDepartment of Medicine, Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY, USA.
Hanieh YaghootkarGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK.
Hannele Yki-JärvinenMinerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Kendra A YoungDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA.
Jake P MannMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Electronic address: jm2032@cam.ac.uk.
University of Cambridge · GBUCLA Medical Center · USCopenhagen University Hospital · DKSaarland University · DEWake Forest University · USEli Lilly (United States) · USTechnische Universität Dresden · DEThe University of Western Australia · AUUniversity of Bristol · GBUniversity of Helsinki · FIUniversity of Michigan · USBroad Institute · USCharité - Universitätsmedizin Berlin · DEChristian-Albrechts-Universität zu Kiel · DEColumbia University · USGeisinger Health System · USNational Institute of Biomedical Genomics · INParacelsus Medical University · ATRWTH Aachen University · DESahlgrenska University Hospital · SE
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTransform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MEngaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MInstitute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4MYale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MUT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5MMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_12015/1Medical Research Council MC UU 12015/5Medical Research Council MR/L022206/1NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000006NCATS NIH HHS UL1 TR000058NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR000436NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR001105NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR002319NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002548NHLBI NIH HHS R01 HL060894NHLBI NIH HHS R01 HL060919NHLBI NIH HHS R01 HL060944NHLBI NIH HHS R01 HL061019NIAAA NIH HHS R01 AA018333NICHD NIH HHS R01 HD028016NIDDK NIH HHS P30 DK045735NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK085175NIDDK NIH HHS R01 DK111038NIDDK NIH HHS R01 DK114504NIDDK NIH HHS R01 DK118062NIDDK NIH HHS U01 DK061713NIDDK NIH HHS U01 DK061718NIDDK NIH HHS U01 DK061728NIDDK NIH HHS U01 DK061730NIDDK NIH HHS U01 DK061731NIDDK NIH HHS U01 DK061732NIDDK NIH HHS U01 DK061734NIDDK NIH HHS U01 DK061737NIDDK NIH HHS U01 DK061738Wellcome Trust 206274/Z/17/ZWellcome Trust 216329/Z/19/Z
Abstract
BACKGROUND &
aimsA common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in NAFLD; however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and to characterise its role in the regulation of related metabolic phenotypes through a meta-analysis.
methodsWe performed a meta-analysis of studies with data on the association between rs641738C>T genotype and liver fat, NAFLD histology, and serum alanine aminotransferase (ALT), lipids or insulin. These included directly genotyped studies and population-level data from genome-wide association studies (GWAS). We performed a random effects meta-analysis using recessive, additive and dominant genetic models.
resultsData from 1,066,175 participants (9,688 with liver biopsies) across 42 studies were included in the meta-analysis. rs641738C>T was associated with higher liver fat on CT/MRI (+0.03 standard deviations [95% CI 0.02-0.05], p
conclusionsOur study validates rs641738C>T near MBOAT7 as a risk factor for the presence and severity of NAFLD in individuals of European descent. LAY SUMMARY: Fatty liver disease is a common condition where fat builds up in the liver, which can cause liver inflammation and scarring (including 'cirrhosis'). It is closely linked to obesity and diabetes, but some genes are also thought to be important. We did this study to see whether one specific change ('variant') in one gene ('MBOAT7') was linked to fatty liver disease. We took data from over 40 published studies and found that this variant near MBOAT7 is linked to more severe fatty liver disease. This means that drugs designed to work on MBOAT7 could be useful for treating fatty liver disease.
Indexed as
Liver CirrhosisNon-alcoholic Fatty Liver DiseaseAcyltransferasesAlanine TransaminaseDrug DiscoveryGenetic Predisposition to DiseaseHumansLiverMembrane ProteinsPolymorphism, Single NucleotideAcyltransferasesAlanine TransaminaseMBOAT7 protein, humanMembrane ProteinsALSPACDiabetesFibrosisMBOAT7NAFLDTriglyceride
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