Evidence map›Paper›PMID 32884031›Full record

ArticleScientific reports2020

Genome-wide association study for circulating fibroblast growth factor 21 and 23.

Gwo-Tsann Chuang, Pi-Hua Liu, Tsui-Wei Chyan, Chen-Hao Huang, Yu-Yao Huang, Chia-Hung Lin, Jou-Wei Lin, Chih-Neng Hsu, Ru-Yi Tsai, Meng-Lun Hsieh and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. TGFβ signaling regulates the response of the skeleton to phosphate.bioRxiv : the preprint server for biology · 2025
    Article
  2. Network Interactions of Circulating FGF23, HRG-HMGB1, and Cardiac Disease in CKD.Journal of the American Society of Nephrology : JASN · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Gwo-Tsann Chuang *Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Pi-Hua Liu *Clinical Informatics and Medical Statistics Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
Tsui-Wei ChyanInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Chen-Hao HuangInstitute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Yu-Yao HuangDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital At Linkou, Taoyuan, Taiwan, ROC.
Chia-Hung LinDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital At Linkou, Taoyuan, Taiwan, ROC.
Jou-Wei LinCardiovascular Center, National Taiwan University Hospital Yun-Lin Branch, Taipei, Taiwan, ROC.
Chih-Neng HsuCardiovascular Center, National Taiwan University Hospital Yun-Lin Branch, Taipei, Taiwan, ROC.
Ru-Yi TsaiCardiovascular Center, National Taiwan University Hospital Yun-Lin Branch, Taipei, Taiwan, ROC.
Meng-Lun HsiehDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Hsiao-Lin LeeDepartment of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Wei-Shun YangGraduate Institute of Medical Genomics and Proteomics, National Taiwan University, 5F, No.2, Xuzhou Rd., Zhongzheng Dist., Taipei, 100, Taiwan, ROC.
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Chia-Ni HsiungData Science Statistical Cooperation Center, Institute of Statistical Science, Academia Sinica, Taipei, Taiwan, ROC.
Chen-Yang ShenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC.
Yi-Cheng ChangGraduate Institute of Medical Genomics and Proteomics, National Taiwan University, 5F, No.2, Xuzhou Rd., Zhongzheng Dist., Taipei, 100, Taiwan, ROC. b83401040@gmail.com.
National Taiwan University · TWNational Taiwan University Hospital · TWChang Gung Memorial Hospital · TWChang Gung University · TWChina Medical University · TWInstitute of Statistical Science, Academia Sinica · TWLinkou Chang Gung Memorial Hospital · TWVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulating metabolism of glucose, lipid, phosphate and vitamin D. Here we conducted a genome-wide association study (GWAS) for circulating FGF21 and FGF23 concentrations to identify their genetic determinants. We enrolled 5,000 participants from Taiwan Biobank for this GWAS. After excluding participants with diabetes mellitus and quality control, association of single nucleotide polymorphisms (SNPs) with log-transformed FGF21 and FGF23 serum concentrations adjusted for age, sex and principal components of ancestry were analyzed. A second model additionally adjusted for body mass index (BMI) and a third model additionally adjusted for BMI and estimated glomerular filtration rate (eGFR) were used. A total of 4,201 participants underwent GWAS analysis. rs67327215, located within RGS6 (a gene involved in fatty acid synthesis), and two other SNPs (rs12565114 and rs9520257, located between PHC2-ZSCAN20 and ARGLU1-FAM155A respectively) showed suggestive associations with serum FGF21 level (P = 6.66 × 10

Indexed as

Body Mass IndexGenome-Wide Association StudyPolymorphism, Single NucleotideAdultAgedBiomarkersFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsHumansMaleMiddle AgedTaiwanVitamin DBiomarkersFGF21 protein, humanFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsVitamin D

Identifiers

PMID32884031
PMCPMC7471933
OpenAlexW3081751712

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.