Evidence map›Paper›PMID 32895173›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020

[Down-regulation of pannexin 2 channel enhances cisplatin-induced apoptosis in testicular cancer I-10 cells].

Yanxue Yao, Shuying Dong, Chenlu Zhu, Miao Hu, Baolong Du, Xuhui Tong

Open access · greenAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Pannexin channels in inflammation and tumorigenesis.Frontiers in cell and developmental biology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanxue YaoSchool of Pharmacy, Bengbu Medical College, Bengbu 233030, China.
Shuying DongSchool of Pharmacy, Bengbu Medical College, Bengbu 233030, China.
Chenlu ZhuSchool of Pharmacy, Bengbu Medical College, Bengbu 233030, China.
Miao HuSchool of Pharmacy, Bengbu Medical College, Bengbu 233030, China.
Baolong DuSchool of Pharmacy, Bengbu Medical College, Bengbu 233030, China.
Xuhui TongSchool of Pharmacy, Bengbu Medical College, Bengbu 233030, China.
Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of down-regulation of pannexin 2 (Panx-2) channels on cisplatin-induced apoptosis in I-10 cells.

methodsThe expression of Panx-2 protein in testicular cancer cells was detected with Western blotting. The testicular cancer cell line I-10 was transfected with two short hairpin RNA (shRNA1 and shRNA2)

resultsThe expression of Panx-2 was significantly increased in cisplatin-resistant I-10/DDP (

conclusionsDown-regulation of Panx-2 channel enhances cisplatin-induced apoptosis in cultured testicular cancer cells.

Indexed as

Testicular NeoplasmsAntineoplastic AgentsApoptosisCell Line, TumorCell ProliferationCisplatinConnexinsDown-RegulationDrug Resistance, NeoplasmHumansMaleAntineoplastic AgentsCisplatinConnexinsPANX2 protein, humanapoptosiscisplatinumpannexin 2testicular cancer

Identifiers

PMID32895173
PMCPMC7429161
OpenAlexW3081541032

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.