Evidence map›Paper›PMID 32896825›Full record

ArticleBlood cells, molecules & diseases2021

Numbers of long-term hematopoietic stem cells from bone marrow of fanca and fancc knockout mice can be greatly enhanced by their collection and processing in physioxia conditions.

Hal E Broxmeyer, Maegan L Capitano, Scott Cooper, Elizabeth Sierra Potchanant, D Wade Clapp

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cells, molecules & diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hal E BroxmeyerDepartments of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: hbroxmey@iupui.edu.
Maegan L CapitanoDepartments of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: malcapit@iupui.edu.
Scott CooperDepartments of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.
Elizabeth Sierra PotchanantDepartments of Microbiology and Pediatrics Indiana University School of Medicine, Indianapolis, IN, USA.
D Wade ClappDepartments of Microbiology and Pediatrics Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Controlling Influences of Oxygen Tension and CD26/DPP4 Enzymatic Activity on Regulation of Hematopoietic Stem/Progenitor Cells and Hematopoiesis During Health, Ageing, and DiseaseR35HL139599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E. · 2018 to 2021
$3.1M
DEK Regulation of Hematopoietic Stem Cell Renewal, Fate, and HematopoiesisR01DK109188 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., MARKOVITZ, DAVID MICHAEL · 2016 to 2019
$2.0M
Mitotic failure in Fanconi anemia: mechanisms and role in carcinogenesisR01HL132921 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CLAPP, DAVID W · 2017 to 2020
$1.8M
NHLBI NIH HHS R01 HL132921NHLBI NIH HHS R35 HL139599NIDDK NIH HHS R01 DK109188NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

Fanconi anemia (FA) is associated with bone marrow failure. Bone marrow (BM) from patients with FA and fanca

Indexed as

AnimalsBone Marrow CellsCell CountCell HypoxiaCells, CulturedCell SeparationFanconi AnemiaFanconi Anemia Complementation Group A ProteinFanconi Anemia Complementation Group C ProteinHematopoietic Stem CellsHumansMiceMice, Inbred C57BLMice, KnockoutFanca protein, mouseFancc protein, mouseFanconi Anemia Complementation Group A ProteinFanconi Anemia Complementation Group C Proteinfanca(−/−) micefancc(−/−) miceHematopoietic stem and progenitor cellsPhysioxia (lowered O(2) tension)

Identifiers

PMID32896825
PMCPMC7686233
OpenAlexW3081558262

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.