SynthesisClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2021
Impact of SARS-CoV-2 Pandemic on Colorectal Cancer Screening Delay: Effect on Stage Shift and Increased Mortality.
Synthesis in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
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Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantifying the impact of treatment delays on breast cancer survival outcomes: a comprehensive meta-analysis.GeroScience · 2026Pooled it
- Impact of the COVID-19 pandemic on surgical outcomes in patients undergoing colorectal cancer surgery: A retrospective study and meta-analysis of data from 11,082 participants.Frontiers in public health · 2022Pooled it
- Risk Stratification to Optimize Colorectal Cancer Screening: Development and Validation of a Decision-Tree Model for Colonoscopy Prioritization.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Article
- Optimizing Colonoscopy Capacity to Maximize Colorectal Cancer Outcomes.Gastro hep advances · 2026Article
- Early budget impact analysis of magnetic balloon technology for facilitating the completion of difficult colonoscopies.Cost effectiveness and resource allocation : C/E · 2025Article
- The impact of extended invitation intervals on stage distribution of screen-detected and interval cancer within the Dutch colorectal cancer screening program.International journal of cancer · 2025Article
- Article
- The COVID-19 pandemic and clinical characteristics of colorectal cancer: a multicenter retrospective study.Scientific reports · 2025Article
- The impact of patient-reported factors of endoscopic screening experience on attendance at future examinations and distal colorectal cancer incidence.BMC cancer · 2025Article
- Disparities in Cancer Stage Shifts Associated with the COVID-19 Pandemic in California, 2020 to 2021.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Estimating the impact of missed colorectal cancer diagnoses on life expectancy in Minamisoma City following the 2011 triple disaster.PloS one · 2025Article
- Impact of the COVID-19 pandemic on the outcomes of colorectal cancer surgical patients treated at a public hospital in Southern Brazil.Frontiers in surgery · 2025Article
- Effect of the COVID-19 pandemic on colorectal cancer screening in two university-affiliated health care systems.PloS one · 2025Article
- The impact of the COVID-19 pandemic on clinical practices related to colorectal cancer and colonoscopy in South Korea: a nationwide population-based study.Intestinal research · 2025Article
- Article
- Stool and blood biomarkers for colorectal cancer management: an update on screening and disease monitoring.Molecular cancer · 2024Review
- Impact of the Swine flu pandemic on General Practitioner (GP) visits in Finland: sex and age differences.BMC primary care · 2024Observational
- Article
- Restricted access and advanced disease in post-pandemic testicular cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- A panorama of colon cancer in the era of liquid biopsy.The journal of liquid biopsy · 2024Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsThe SARS-CoV-2 pandemic had a sudden, dramatic impact on healthcare. In Italy, since the beginning of the pandemic, colorectal cancer (CRC) screening programs have been forcefully suspended. We aimed to evaluate whether screening procedure delays can affect the outcomes of CRC screening.
methodsWe built a procedural model considering delays in the time to colonoscopy and estimating the effect on mortality due to up-stage migration of patients. The number of expected CRC cases was computed by using the data of the Italian screened population. Estimates of the effects of delay to colonoscopy on CRC stage, and of stage on mortality were assessed by a meta-analytic approach.
resultsWith a delay of 0-3 months, 74% of CRC is expected to be stage I-II, while with a delay of 4-6 months there would be a 2%-increase for stage I-II and a concomitant decrease for stage III-IV (P = .068). Compared to baseline (0-3 months), moderate (7-12 months) and long (> 12 months) delays would lead to a significant increase in advanced CRC (from 26% to 29% and 33%, respectively; P = .008 and P < .001, respectively). We estimated a significant increase in the total number of deaths (+12.0%) when moving from a 0-3-months to a >12-month delay (P = .005), and a significant change in mortality distribution by stage when comparing the baseline with the >12-months (P < .001).
conclusionsScreening delays beyond 4-6 months would significantly increase advanced CRC cases, and also mortality if lasting beyond 12 months. Our data highlight the need to reorganize efforts against high-impact diseases such as CRC, considering possible future waves of SARS-CoV-2 or other pandemics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.