Evidence map›Paper›PMID 32898768›Full record

ReviewCurrent opinion in microbiology2020

Sensing the threat posed by Aspergillus infection.

Joshua J Obar

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. The Contribution of Human Antimicrobial Peptides to Fungi.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Potential Antifungal Targets forInternational journal of molecular sciences · 2022
    Review
  6. Article
  7. Review
  8. Dysregulation of Key Proteinases inReports of biochemistry & molecular biology · 2021
    Article
  9. Molecular Epidemiology ofJournal of fungi (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Joshua J ObarGeisel School of Medicine at Dartmouth, Department of Microbiology & Immunology, Hinman Box 7556, 1 Medical Center Drive, Lebanon, NH 03756, USA. Electronic address: joshua.j.obar@dartmouth.edu.

Funding

Fungal spore sensing by MDA5 is necessary for antifungal immunity against Aspergillus fumigatusR01AI139133 · NIAID · DARTMOUTH COLLEGE · PI JOSHUA J OBAR · 2019 to 2026
$3.6M
Development of an influenza A virus and Aspergillus fumigatus coinfection modelR21AI152019 · NIAID · DARTMOUTH COLLEGE · PI OBAR, JOSHUA J · 2020 to 2021
$451k
NIAID NIH HHS R01 AI139133NIAID NIH HHS R21 AI152019
6 · The paper itself

Abstract

The mammalian immune system can tune its inflammatory response to the threat level posed by an invading pathogen. It is well established that the host utilizes numerous 'patterns of pathogenicity', such as microbial growth, invasion, and viability, to achieve this tuning during bacterial infections. This review discusses how this notion fits during fungal infection, particularly regarding Aspergillus fumigatus infection. Moreover, how the environmental niches filled by A. fumigatus may drive the evolution of the fungal traits responsible for inducing the strain-specific inflammatory responses that have been experimentally observed will be discussed. Moving forward understanding the mechanisms of the fungal strain-specific inflammatory response due to the initial interactions with the host innate immune system will be essential for enhancing our therapeutic options for the treatment of invasive fungal infections.

Indexed as

AnimalsAspergillosisAspergillus fumigatusFungal ProteinsHumansInvasive Fungal InfectionsFungal Proteins

Identifiers

PMID32898768
PMCPMC7746570

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.