ReviewCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine2020
Albumin as a drug: its biological effects beyond volume expansion.
Review in Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Hyperoncotic Albumin (20%) Versus Crystalloids for Mortality in Adults with Sepsis and Septic Shock: An Updated Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Preoperative GNRI and surgical site infection risk after total joint arthroplasty: A systematic review and meta-analysis.Biomolecules & biomedicine · 2026Pooled it
- Prognostic value of the Geriatric Nutritional Risk Index in patients undergoing cardiac surgery: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- The effect of human albumin administration on postoperative renal function following major surgery: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial.Intensive care medicine · 2024Trial
- Admission Serum Albumin as a Predictor of Cardiovascular Complications in Non-Traumatic Intracerebral Hemorrhage.Journal of clinical medicine · 2026Article
- Design, Synthesis and Biological Evaluation of Novel SN38 Based Albumin-Binding Peptide-Drug Conjugates in Pancreatic Ductal Adenocarcinoma.Pharmaceutics · 2026Article
- The Acid-Base Effects of Albumin in Sepsis: Reconciling the Stewart Physicochemical Approach with the Traditional Buffer-Base Paradigm.Journal of clinical medicine · 2026Review
- Albumin in Cardiac Surgery-Associated Acute Kidney Injury: Therapeutic Target or Epiphenomenon?Annals of cardiac anaesthesia · 2026Article
- Food-grade utilization of bovine slaughterhouse by-products for developing cost-effective media supplements in cultivated meat applications.Food science of animal resources · 2026Review
- Article
- The red cell distribution width to albumin ratio (RAR) for predicting prognosis in spontaneous intracerebral hemorrhage: a retrospective cohort study using the MIMIC-IV database.Scientific reports · 2026Article
- Use of Human Serum Albumin in Critically Ill Patients: A Narrative Review.Journal of clinical medicine · 2026Review
- Early albumin infusion and mortality in ICU patients with HFpEF: a target trial emulation study.European journal of clinical pharmacology · 2026Article
- Albumin kinetics, intravascular fluid volume, and respiratory function in pigs ventilated at different levels of mechanical power following crystalloid vs. albumin infusion.Intensive care medicine experimental · 2026Article
- Antibodies in plasma and blood cells of horses.Open veterinary journal · 2026Article
- A paradigm-expanding role for albumin: Metal-free, protein-mediated nitrite bioactivation.Free radical biology & medicine · 2026Article
- Association of albumin trajectories and cumulative exposure with in-hospital mortality in acute pancreatitis: a retrospective cohort study.International journal of surgery (London, England) · 2026Article
- Exploring the predictors of postoperative complications in hand surgery: a cross-sectional analysis.BMC surgery · 2025Article
- Rinaldo Bellomo: A clinician with a passion for preclinical research.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Albumin is the most abundant and perhaps most important protein in human blood. Research has identified many of albumin's possible roles in modulating acid-base balance, modifying inflammation, maintaining vascular endothelial integrity, and binding endogenous and exogenous compounds. Albumin plays a key role in the homeostasis of vascular endothelium, offering protection from inflammation and damage to the glycocalyx. Albumin binds a diverse range of compounds. It transports, delivers and clears drugs, plus it helps with uptake, storage and disposal of potentially harmful biological products. The biological effects of albumin in critical illness are incompletely understood, but may enhance its clinical role beyond use as an intravenous fluid. In this article, we summarise the evidence surrounding albumin's biological and physiological effects beyond its use for plasma volume expansion, and explore potential mechanistic effects of albumin as a disease modifier in patients with critical illness.
Indexed as
Identifiers
32900333PMC10692529W3086896819What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.