ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Long-term Infective Endocarditis Mortality Associated With Injection Opioid Use in the United States: A Modeling Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- A comprehensive review of state laws that govern the distribution and possession of drug use equipment in the United States.The International journal on drug policy · 2026Review
- Improving hospital-based care for patients with injection-drug related infections: provider perspectives.Addiction science & clinical practice · 2026Article
- Clinical Severity and Surgical Burden in Drug Use-Associated Infective Endocarditis: A Six-Year Cohort Study.Microorganisms · 2026Article
- Health, Costs, and Injection-Related Infections at a Hypothetical Overdose Prevention Center.JAMA network open · 2026Article
- Trends and disparities in mortality from infective endocarditis in the United States, 1999-2023: a nationwide analysis.Frontiers in cardiovascular medicine · 2026Article
- Outcomes in skilled nursing facilities versus other locations in outpatient parenteral antimicrobial therapy among patients with substance use disorders.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- The Housing Instability Scale: Determining a Cutoff Score and Its Utility for Contextualizing Health Outcomes in People Who Use Drugs.International journal of environmental research and public health · 2025Article
- Bacterial and fungal infections in persons who inject drugs.Clinical microbiology reviews · 2025Review
- Ethical Management of Challenging Behaviors in Hospitalized People Who Use Drugs.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Risk Factors for Infective Endocarditis and Serious Injection Related Infections Among People Who Inject Drugs in Los Angeles, CA and Denver, CO.Drug and alcohol dependence · 2025Article
- Self-Reported Illicitly Manufactured Fentanyl Use and Associated Health and Substance Use Risks in the United States, 2022.Substance use & misuse · 2025Article
- Management of People Who Inject Drugs With Serious Injection-Related Infections in an Outpatient Setting: A Scoping Review.Open forum infectious diseases · 2024Article
- Colocating Syringe Services, COVID-19 Vaccination, And Infectious Disease Testing: Baltimore's Experience.Health affairs (Project Hope) · 2024Article
- Strategies to Improve Patient-Centered Care for Drug Use-Associated Infective Endocarditis: JACC Focus Seminar 2/4.Journal of the American College of Cardiology · 2024Review
- Project CHARIOT: study protocol for a hybrid type 1 effectiveness-implementation study of comprehensive tele-harm reduction for engagement of people who inject drugs in HIV prevention services.Addiction science & clinical practice · 2024Article
- Drug preparation, injection-related infections, and harm reduction practices among a national sample of individuals entering treatment for opioid use disorder.Harm reduction journal · 2024Article
- At a Crossroads: Opioid Use Disorder, the X-Waiver, and the Road Ahead.Ochsner journal · 2024Review
- Epidemiology of acute infections in people who inject drugs in Australia.Drug and alcohol review · 2024Review
- A multimorbidity model for estimating health outcomes from the syndemic of injection drug use and associated infections in the United States.BMC health services research · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe expansion of the US opioid epidemic has led to significant increases in infections, such as infective endocarditis (IE), which is tied to injection behaviors. We aimed to estimate the population-level IE mortality rate among people who inject opioids and compare the risk of IE death against the risks of death from other causes.
methodsWe developed a microsimulation model of the natural history of injection opioid use. We defined injection behavior profiles by both injection frequency and injection techniques. We accounted for competing risks of death and populated the model with primary and published data. We modeled cohorts of 1 million individuals with different injection behavior profiles until age 60 years. We combined model-generated estimates with published data to project the total expected number of IE deaths in the United States by 2030.
resultsThe probabilities of death from IE by age 60 years for 20-, 30-, and 40-year-old men with high-frequency use with higher infection risk techniques compared to lower risk techniques for IE were 53.8% versus 3.7%, 51.4% versus 3.1%, and 44.5% versus 2.2%, respectively. The predicted population-level attributable fraction of 10-year mortality from IE among all risk groups was 20%. We estimated that approximately 257 800 people are expected to die from IE by 2030.
conclusionsThe expected burden of IE among people who inject opioids in the United States is large. Adopting a harm reduction approach, including through expansion of syringe service programs, to address injection behaviors could have a major impact on decreasing the mortality rate associated with the opioid epidemic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.