Evidence map›Paper›PMID 32902163›Full record

ArticleGenes, brain, and behavior2021

Cell-type specific knockout of peptidylglycine α-amidating monooxygenase reveals specific behavioral roles in excitatory forebrain neurons and cardiomyocytes.

Kathryn G Powers, Xin-Ming Ma, Betty A Eipper, Richard E Mains

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kathryn G PowersDepartment of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA.
Xin-Ming MaDepartment of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA.
Betty A EipperDepartment of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA.ORCID 0000-0003-1171-5557
Richard E MainsDepartment of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA.ORCID 0000-0003-1154-1331
UConn Health · US

Funding

CELL BIOLOGY OF BIOACTIVE PEPTIDE SECRETIONR01DK032948 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH ANNE, MAINS, RICHARD E · 1986 to 2019
$7.3M
Cell Biology of Bioactive Peptide SecretionR56DK032948 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MAINS, RICHARD E · 2008 to 2008
$303k
NIDDK NIH HHS R01 DK032948NIDDK NIH HHS R56 DK032948
6 · The paper itself

Abstract

Neuropeptides and peptide hormones play a crucial role in integrating the many factors that affect physiologic and cognitive processes. The potency of many of these peptides requires an amidated amino acid at the C-terminus; a single enzyme, peptidylglycine α-amidating monooxygenase (PAM), catalyzes this modification. Anxiety-like behavior is known to be altered in mice with a single functional Pam allele (Pam

Indexed as

Exploratory BehaviorMaze LearningAnimalsFemaleMaleMiceMice, Inbred C57BLMixed Function OxygenasesMultienzyme ComplexesMyocytes, CardiacNeuronsProsencephalonSocial BehaviorMixed Function OxygenasesMultienzyme Complexespeptidylglycine monooxygenaseamygdalaanxiety-like behaviorBarnes mazeEmx1glutamic acid decarboxylaseimmunocytochemistryMyh6neuropeptidesnovel object recognitionsociability test

Identifiers

PMID32902163
PMCPMC7858240
OpenAlexW3085097863

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.