Evidence map›Paper›PMID 32904944›Full record

ArticleJBMR plus2021

Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti-Inflammatory.

Emma L Bishop, Aiten Ismailova, Sarah Dimeloe, Martin Hewison, John H White

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 10 pooled it
28.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 10 syntheses or guidelines pooled it, 360 citations in OpenAlex.

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  11. Effects of personalized vitamin DBritish journal of cancer · 2026
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Emma L BishopInstitute of Immunology and Immunotherapy University of Birmingham Birmingham UK.
Aiten IsmailovaDepartment of Physiology McGill University Montreal Quebec Canada.
Sarah DimeloeInstitute of Immunology and Immunotherapy University of Birmingham Birmingham UK.
Martin HewisonMetabolism and Systems Research University of Birmingham Birmingham UK.ORCID https://orcid.org/0000-0001-5806-9690
John H WhiteDepartment of Physiology McGill University Montreal Quebec Canada.
Health First · USUniversity of Birmingham · GBMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of immune function continues to be one of the most well-recognized extraskeletal actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells such as macrophages could actively metabolize precursor 25-hydroxyvitamin D (25D) to active 1,25-dihydroxyvitamin D (1,25D). Parallel observation that activated cells from the immune system expressed the intracellular vitamin D receptor (VDR) for 1,25D suggested a potential role for vitamin D as a localized endogenous modulator of immune function. Subsequent studies have expanded our understanding of how vitamin D exerts effects on both the innate and adaptive arms of the immune system. At an innate level, intracrine synthesis of 1,25D by macrophages and dendritic cells stimulates expression of antimicrobial proteins such as cathelicidin, as well as lowering intracellular iron concentrations via suppression of hepcidin. By potently enhancing autophagy, 1,25D may also play an important role in combatting intracellular pathogens such as

Indexed as

ANTIBACTERIALAUTOPHAGYCATHELICIDINHEPCIDININFLAMMATIONNOD2Th1Th17TregVITAMIN Dβ‐DEFENSIN 2

Identifiers

PMID32904944
PMCPMC7461279
OpenAlexW3080411302

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.