Evidence map›Paper›PMID 32907543›Full record

SynthesisBMC immunology2020

Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies.

Vuyolwethu Mxinwa, Phiwayinkosi V Dludla, Tawanda M Nyambuya, Kabelo Mokgalaboni, Sithandiwe E Mazibuko-Mbeje, Bongani B Nkambule

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vuyolwethu MxinwaSchool of Laboratory Medicine and Medical Sciences (SLMMS), College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
Phiwayinkosi V DludlaDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy.
Tawanda M NyambuyaSchool of Laboratory Medicine and Medical Sciences (SLMMS), College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
Kabelo MokgalaboniSchool of Laboratory Medicine and Medical Sciences (SLMMS), College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
Sithandiwe E Mazibuko-MbejeBiomedical Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa.
Bongani B NkambuleSchool of Laboratory Medicine and Medical Sciences (SLMMS), College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa. nkambuleb@ukzn.ac.za.ORCID 0000-0001-8846-1992

Funding

FIC NIH HHS D43 TW010131National Research Foundation (ZA) 107519South African Medical Research Council 9894
6 · The paper itself

Abstract

backgroundChronic immune activation and hyperglycaemia are a hallmark of type 2 diabetes mellitus (T2D) while natural killer (NK) cells are involved in the pathogenesis of T2D. Dysregulated NK cell responses are associated with an increased risk of cardiovascular disease in patients living with T2D.

objectiveTo provide a comprehensive and systematic evidence-based estimate on the levels of NK cells in patients living with T2D.

resultsThis systematic review and meta-analysis included 13 studies reporting on 491 adult patients with T2D and 1064 nondiabetic controls. The pooled effect estimates showed increased levels of NK cells in adult patients with T2D compared to controls (MD: 0.03 [- 3.20, 3.26], I

conclusionOverall, the evidence presented in this systematic review shows that the changes in NK cells in patients living with T2D are still unclear and further studies are needed.

Indexed as

AdultCardiovascular DiseasesDiabetes Mellitus, Type 2Evidence-Based MedicineHumansImmunity, InnateKiller Cells, NaturalLymphocyte CountRiskCardiovascular diseasesInflammationNatural killer cellsType 2 diabetes mellitus

Identifiers

PMID32907543
PMCPMC7487809

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.