Trial reportPediatric obesity2021
Adiposity and cardiovascular outcomes in three-year-old children of participants in UPBEAT, an RCT of a complex intervention in pregnant women with obesity.
Trial report in Pediatric obesity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The effect of methods used in the management of maternal obesity on pregnancy and birth outcomes: a systematic review with meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Maternal obesity and offspring cardiovascular remodelling - the effect of preconception and antenatal lifestyle interventions: a systematic review.International journal of obesity (2005) · 2024Pooled it
- Physical activity and gestational weight gain: a systematic review of observational studies.BMC public health · 2022Pooled it
- Pooled it
- Child somatic growth and neurodevelopment: effects of pregnancy lifestyle intervention.Pediatric research · 2025Trial
- A preconception lifestyle intervention in women with obesity and cardiovascular health in their children.Pediatric research · 2023Trial
- Lifestyle intervention in obese pregnancy and cardiac remodelling in 3-year olds: children of the UPBEAT RCT.International journal of obesity (2005) · 2022Trial
- Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity.The Journal of clinical endocrinology and metabolism · 2022Trial
- Trial
- Effect of prenatal lifestyle intervention on maternal postpartum weight retention and child body mass index z-score at 36 months.International journal of obesity (2005) · 2021Trial
- Trial
- Real World Evidence Versus Randomised Controlled Trials: Is the Future of Nutritional Sciences Research in Electronic Health Records?Nutrition bulletin · 2026Review
- Precision Prevention, Diagnostics, and Treatment of Obesity: Pipedream or Reality?Obesity (Silver Spring, Md.) · 2025Review
- Lifestyle-based and psychological interventions during pregnancy and risk of obesity and obesity-associated metabolic complications in the offspring: A scoping review.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Characterization of human placental fetal vessels in gestational diabetes mellitus.Pflugers Archiv : European journal of physiology · 2025Article
- Physical Activity during Pregnancy and Childhood Obesity: Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Early life impacts of maternal obesity: a window of opportunity to improve the health of two generations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The Uterine Environment and Childhood Obesity Risk: Mechanisms and Predictions.Current nutrition reports · 2023Review
- Longitudinal dietary trajectories from pregnancy to 3 years post delivery in women with obesity: relationships with adiposity.Obesity (Silver Spring, Md.) · 2023Article
- Nutritional Programming: History, Hypotheses, and the Role of Prenatal Factors in the Prevention of Metabolic Diseases-A Narrative Review.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundMaternal obesity is associated with offspring cardiometabolic risk. UPBEAT was a randomised controlled trial of an antenatal diet and physical activity intervention in 1555 women with obesity. The intervention was associated with lower gestational weight gain, healthier diet and metabolic profile in pregnancy, and reduced infant adiposity at six months.
objectiveWe have investigated whether the UPBEAT intervention influenced childhood cardiometabolic outcomes or was associated with sustained improvements in maternal lifestyle 3-years after delivery.
methodsIn UPBEAT mother-child dyads at the 3-year follow-up, we assessed childhood blood pressure, resting pulse rate, and adiposity (body mass index, skinfold thicknesses, body fat, waist and arm circumferences) and maternal diet, physical activity, and anthropometry.
results514 three-year-old children attended the appointment (49% intervention, 51% standard care). There was no difference in the main outcome of interest, subscapular skinfold thickness, between the trial arms (-0.30 mm, 95% confidence interval: -0.92, 0.31). However, the intervention was associated with a lower resting pulse rate (-5 bpm [-8.41, -1.07]). There was also a non-significant lower odds of overweight/obesity (OR 0.73; 0.50, 1.08). Maternal dietary improvements observed in the UPBEAT trial, including glycaemic load and saturated fat were maintained 3-years postpartum.
conclusionThis study has demonstrated that an antenatal dietary and physical activity intervention in women with obesity is associated with lower offspring pulse rate and sustained improvement in maternal diet. Whilst larger than previous cohorts, there remains potential for bias from attrition and these findings require validation in future cohorts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.