Evidence map›Paper›PMID 32915675›Full record

ArticlePharmaceutical biology2020

Luping Zhang, Bo Meng, Lanzhou Li, Yanzhen Wang, Yuanzhu Zhang, Xuexun Fang, Di Wang

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Anti-Obesity Effect ofNutrients · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Luping ZhangGastroenterology and Endoscopy Center, The First Bethune Hospital of Jilin University, Jilin University, Changchun, China.
Bo MengGastroenterology and Endoscopy Center, The First Bethune Hospital of Jilin University, Jilin University, Changchun, China.
Lanzhou LiKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.
Yanzhen WangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.
Yuanzhu ZhangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.
Xuexun FangGastroenterology and Endoscopy Center, The First Bethune Hospital of Jilin University, Jilin University, Changchun, China.
Di WangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.
Jilin University · CNFirst Bethune Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextAlcoholic liver disease, caused by abuse and consumption of alcohol, exhibits high morbidity and mortality.

objectivesTo investigate the hepatoprotective effects of BA using an acute alcohol-induced hepatotoxicity mice model. MATERIALS AND

methodsThe composition of BA fruit body was first systematically analyzed. Subsequently, a C57BL/6 mice model of acute alcohol-induced liver injury was established by intragastrically administration of alcohol, which was intragastrically received with BA powder at 200 mg/kg and 800 mg/kg for 2 weeks, 60 mg/kg silybin treatment was used as positive control group. By employing the pathological examination, ELISA, RT-PCR and western blot, the regulation of BA on oxidative stress signals was investigated.

resultsThe LD

conclusionsBA is effective in ameliorating alcohol-induced liver injury through regulating oxidative stress-mediated NF-κB signalling, which provides a scientific basis for further research on its clinical applications.

Indexed as

AnimalsAnti-Inflammatory AgentsAntioxidantsBasidiomycotaChemical and Drug Induced Liver InjuryKidneyLiverLiver Diseases, AlcoholicMaleMiceMice, Inbred C57BLModels, AnimalNF-kappa BOxidative StressProtective AgentsSerumAnti-Inflammatory AgentsAntioxidantsNF-kappa BProtective Agentsalcohol metabolismHepatoprotectiveinflammationreactive oxygen species

Identifiers

PMID32915675
PMCPMC7534317
OpenAlexW3085308017

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.