Evidence map›Paper›PMID 32924316›Full record

SynthesisCancer medicine2020

Sarcopenia and adverse health-related outcomes: An umbrella review of meta-analyses of observational studies.

Lin Xia, Rui Zhao, Qianyi Wan, Yutao Wu, Yong Zhou, Yong Wang, Yaping Cui, Xiaoding Shen, Xiaoting Wu

2 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 185 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 23 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06094413 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effects of an 8-week Multicomponent Training Program on Quality of Life, Fear of Falling, &Amp; Physical Performance in Community-Dwelling Older Adults

TypeinterventionalSponsorGeisinger ClinicRan2024 to 2024Enrolled20ConditionsSarcopeniaArmsMulticomponent Training Intervention
NCT06614699 active not recruitingnot on this map

Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Short- and Long-term Outcomes in Patients with Colorectal Cancer

TypeobservationalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2012 to 2025Enrolled8,000ConditionsColorectal Cancer, Sarcopenia, Obesity and OverweightArmsabdominal fat and muscle area
3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 23 syntheses or guidelines pooled it, 299 citations in OpenAlex.

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  4. How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review.Journal of cachexia, sarcopenia and muscle · 2026
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  19. Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis.International journal of clinical practice · 2022
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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lin XiaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Rui ZhaoDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Qianyi WanDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yutao WuDepartment of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yong ZhouDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yong WangDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Yaping CuiDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Xiaoding ShenDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Xiaoting WuDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-3996-868X
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this umbrella review was to assess the associations between sarcopenia and adverse health-related outcomes.

designAn umbrella review of meta-analyses of observational studies. SETTING AND

participantsPatients with sarcopenia and controls without sarcopenia were included. MEASURES: The PubMed, Web of Science and Embase were searched for relevant systematic review and meta-analysis. AMSTAR and GRADE system were used for methodological quality and evidence quality assessments, respectively.

resultsTotally 54 outcomes extracted from 30 meta-analyses were analyzed. Twenty out of 21 prognostic outcomes indicated that sarcopenia was significantly associated with poorer prognosis of gastric cancer, hepatocellular cancer, urothelial cancer, head and neck cancer, hematological malignancy, pancreatic cancer, breast cancer, colorectal cancer, lung cancer, esophageal cancer, and ovarian cancer. Besides, 10 out of 16 postoperative outcomes suggested that sarcopenia significantly increased the risk of multiple postoperative complications and prolonged the length of hospitalization of patients with digestive cancer. In age-related outcomes, sarcopenia significantly increased the risk of dysphagia, cognitive impairment, fractures, falls, hospitalization, and all-cause mortality of elderly populations. Moreover, sarcopenia was also associated with higher level of albuminuria, risk of depression, and several metabolic diseases. CONCLUSIONS AND IMPLICATIONS: Sarcopenia significantly affected a wide range of adverse health-related outcomes, particularly in patients of tumor and elderly populations. Because evidences of most outcomes were rated as "low" and "very low," more prospective cohort studies are required in the future.

Indexed as

AgedAge FactorsComorbidityFemaleHealth StatusHumansMaleMeta-Analysis as TopicMiddle AgedObservational Studies as TopicPrognosisRisk AssessmentRisk FactorsSarcopeniaSystematic Reviews as TopicAMSTARGRADEhealth-related outcomessarcopeniaumbrella review

Identifiers

PMID32924316
PMCPMC7643685
OpenAlexW3085502309

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.