ArticleDiabetes2020
Deciphering the Plasma Proteome of Type 2 Diabetes.
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Exploring Biomarkers in Type 2 Diabetes Mellitus versus Normoglycemia Identified through High-Throughput Proteomics: A Systematic Review and Meta-Analysis.Journal of proteome research · 2026Pooled it
- Plasma protein signatures of adult asthma.Allergy · 2024Pooled it
- Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses.Cell reports. Medicine · 2023Pooled it
- Pooled it
- Large-Scale Proteomics Uncovers Pre-Disease Inflammation-Lipid Subtypes to Refine Risk Stratification and Prediction of Type 2 Diabetes.Diabetes, obesity & metabolism · 2026Article
- Proteomic Signatures of 3-Year Progression From Impaired Fasting Glucose to Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.Diabetes care · 2026Article
- Inflammatory Proteomic Heterogeneity Beyond Glycemia Status in Severe Obesity.International journal of molecular sciences · 2026Article
- The Central Role of Lipid Metabolism Disorders in Diabetes Mellitus: Mechanisms, Clinical Manifestations, and Emerging Therapeutic Strategies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Bone Marker Proteins at Baseline and After Insulin-Induced Hypoglycaemia in Type 2 Diabetes.International journal of molecular sciences · 2025Article
- Hyperglycemia correlated with elevated circulating aminoacylase 1 in patients with pre-diabetes and type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- Genetic determinants of proteomic aging.npj aging · 2025Article
- DNA methylation-predicted plasma protein levels and breast cancer risk.Breast cancer research : BCR · 2025Article
- Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease.Diabetes, obesity & metabolism · 2025Article
- Interconnections between BDH1-plasma protein-type 2 diabetes Mellitus: a mediated mendelian randomization analysis using plasma proteomics.Scientific reports · 2025Article
- Novel therapeutic targets for metabolism-related diseases: proteomic Mendelian randomization and colocalization analyses.Therapeutic advances in endocrinology and metabolism · 2025Article
- Identification and validation of up-regulated TNFAIP6 in osteoarthritis with type 2 diabetes mellitus.Scientific reports · 2024Article
- Longitudinal clinical and proteomic diabetes signatures in women with a history of gestational diabetes.JCI insight · 2024Article
- Association of plasma proteomics with mortality in individuals with and without type 2 diabetes: Results from two population-based KORA cohort studies.BMC medicine · 2024Article
- Proteomic Analyses in Diverse Populations Improved Risk Prediction and Identified New Drug Targets for Type 2 Diabetes.Diabetes care · 2024Article
- Association of plasma proteomics with incident coronary heart disease in individuals with and without type 2 diabetes: results from the population-based KORA study.Cardiovascular diabetology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 8 institutions in 6 countries.
Mohamed A ElhadadResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany waldenberger@helmholtz-muenchen.de mohamed.elhadad@helmholtz-muenchen.de.ORCID 0000-0002-6758-8369
Christian JonassonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Cornelia HuthInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0003-2421-433X
Rory WilsonResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Pamela MatiasResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Johannes GraumannBiomolecular Mass Spectrometry, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Valerie Gailus-DurnerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Wolfgang RathmannGerman Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Christine von ToerneResearch Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-4132-4322
Stefanie M HauckResearch Unit Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Wolfgang KoenigGerman Research Center for Cardiovascular Disease (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Moritz F SinnerGerman Research Center for Cardiovascular Disease (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Tudor I OpreaDepartment of Internal Medicine and UNM Comprehensive Cancer Center, University of New Mexico School of Medicine, Albuquerque, NM.
Karsten SuhreDepartment of Biophysics and Physiology, Weill Cornell Medicine - Qatar, Education City, Doha, Qatar.
Barbara ThorandInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0002-8416-6440
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany waldenberger@helmholtz-muenchen.de mohamed.elhadad@helmholtz-muenchen.de.ORCID 0000-0003-0583-5093
Helmholtz Zentrum München · DENorwegian University of Science and Technology · NODeutsches Diabetes-Zentrum e.V. · DEGerman Centre for Cardiovascular Research · DEMax Planck Institute for Heart and Lung Research · DEUniversität Ulm · DEUniversity of Copenhagen · DKWeill Cornell Medical College in Qatar · QA
Funding
Illuminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)U24TR002278 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LARRY A. SKLAR, Stephan C Schurer · 2021 to 2023
$2.1MKnowledge Management Center for Illuminating the Druggable GenomeU24CA224370 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jeremy S Edwards · 2022 to 2022
$1.1MNCATS NIH HHS U24 TR002278NCI NIH HHS U01 CA239108NCI NIH HHS U24 CA224370
Abstract
With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations between type 2 diabetes and >1,000 plasma proteins in the Cooperative Health Research in the Region of Augsburg (KORA) F4 cohort (
Indexed as
BiomarkersBlood ProteinsDiabetes Mellitus, Type 2Gene Expression RegulationGenome-Wide Association StudyHumansProteomicsBiomarkersBlood Proteins
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.