ArticleScientific reports2020
Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala populations than koala retrovirus subtypes.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Current status and future directions ofFrontiers in veterinary science · 2026Pooled it
- Improved high-throughput MHC typing for non-model species using long-read sequencing.Molecular ecology resources · 2022Pooled it
- Development and Validation of a Standardised Genomic Tool for Conservation Management of the Koala (Animals : an open access journal from MDPI · 2025Article
- Adaptive evolution of koala retrovirus transcription silencing and what it means for conservation.Clinical and translational medicine · 2025Article
- Road to Extinction? Past and Present Population Structure and Genomic Diversity in the Koala.Molecular biology and evolution · 2025Article
- Dominance of Vaccine-SpecificEcology and evolution · 2025Article
- Correlation BetweenJournal of fungi (Basel, Switzerland) · 2025Article
- Koala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches.Scientific reports · 2024Article
- Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas.Immunogenetics · 2024Article
- Epidemiology, Transmission Mode, and Pathogenesis ofAnimals : an open access journal from MDPI · 2024Review
- Plethora of New Marsupial Genomes Informs Our Knowledge of Marsupial MHC Class II.Genome biology and evolution · 2024Article
- A retrospective epidemiological study of sarcoptic mange in koalas (International journal for parasitology. Parasites and wildlife · 2024Article
- Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China.BMC infectious diseases · 2024Article
- A novel multi-variate immunological approach, reveals immune variation associated with environmental conditions, and co-infection in the koala (Phascolarctos cinereus).Scientific reports · 2024Article
- Koala ocular disease grades are defined by chlamydial load changes and increases in Th2 immune responses.Frontiers in cellular and infection microbiology · 2024Article
- Article
- Best genome sequencing strategies for annotation of complex immune gene families in wildlife.GigaScience · 2022Article
- Emerging and well-characterized chlamydial infections detected in a wide range of wild Australian birds.Transboundary and emerging diseases · 2022Article
- A targeted approach to investigating immune genes of an iconic Australian marsupial.Molecular ecology · 2022Article
- Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas.PLoS pathogens · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydial disease control is increasingly utilised as a management tool to stabilise declining koala populations, and yet we have a limited understanding of the factors that contribute to disease progression. To examine the impact of host and pathogen genetics, we selected two geographically separated south east Queensland koala populations, differentially affected by chlamydial disease, and analysed koala major histocompatibility complex (MHC) genes, circulating strains of Chlamydia pecorum and koala retrovirus (KoRV) subtypes in longitudinally sampled, well-defined clinical groups. We found that koala immunogenetics and chlamydial genotypes differed between the populations. Disease progression was associated with specific MHC alleles, and we identified two putative susceptibility (DCb 03, DBb 04) and protective (DAb 10, UC 01:01) variants. Chlamydial genotypes belonging to both Multi-Locus Sequence Typing sequence type (ST) 69 and ompA genotype F were associated with disease progression, whereas ST 281 was associated with the absence of disease. We also detected different ompA genotypes, but not different STs, when long-term infections were monitored over time. By comparison, KoRV profiles were not significantly associated with disease progression. These findings suggest that chlamydial genotypes vary in pathogenicity and that koala immunogenetics and chlamydial strains are more directly involved in disease progression than KoRV subtypes.
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