Evidence map›Paper›PMID 32929176›Full record

SynthesisJournal of human genetics2021

Identification of pleiotropic loci underlying hip bone mineral density and trunk lean mass.

Gui-Juan Feng, Xin-Tong Wei, Hong Zhang, Xiao-Lin Yang, Hui Shen, Qing Tian, Hong-Wen Deng, Lei Zhang, Yu-Fang Pei

Abstract readMeta-Analysis
In one paragraph

Synthesis in Journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gui-Juan FengDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China.
Xin-Tong WeiDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China.
Hong ZhangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Jiangsu, People's Republic of China.
Xiao-Lin YangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Jiangsu, People's Republic of China.
Hui ShenDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.ORCID http://orcid.org/0000-0003-0335-6064
Qing TianDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Hong-Wen DengDepartment of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. hdeng2@tulane.edu.ORCID http://orcid.org/0000-0002-0387-8818
Lei ZhangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Jiangsu, People's Republic of China. lzhang6@suda.edu.cn.ORCID http://orcid.org/0000-0002-9157-0759
Yu-Fang PeiDepartment of Epidemiology and Health Statistics, School of Public Health, Medical College of Soochow University, Jiangsu, People's Republic of China. ypei@suda.edu.cn.ORCID http://orcid.org/0000-0002-1007-4834

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Tanika Nicole Kelly · 2016 to 2026
$25.3M
Trans-omics Integration of Multi-omics Studies for OsteoporosisU19AG055373 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI HONG-WEN DENG · 2017 to 2026
$24.3M
RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet InterventionsR01DK115679 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Lu Qi · 2018 to 2026
$5.3M
Male/Female differences in psychosis and mood disorders:Dynamic imaging-genomic models for characterizing and predicting psychosis and mood dR01MH118695 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2019 to 2023
$3.8M
Epigenomewide DNA Methylation Study for Osteoporosis RiskR01AR059781 · NIAMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, HONG-WEN · 2012 to 2016
$3.1M
Identification of Metabolomic Profiles for Sarcopenia Traits in Older Whites and BlacksR01AG061917 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SHEN, HUI, ZHAO, QI · 2019 to 2023
$3.0M
Decoding Methylation Mediated Epigenomic Contributions to Male OsteoporosisR01AR069055 · NIAMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, HONG-WEN · 2017 to 2021
$2.9M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Integration of brain imaging with genomic and epigenomic dataR01MH104680 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI CALHOUN, VINCE D, DENG, HONG-WEN · 2014 to 2017
$2.1M
Integration of fMRI imaging, genomics, network and biological knowledgeR01MH107354 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI WANG, YU-PING · 2015 to 2018
$1.9M
National Natural Science Foundation of China (National Science Foundation of China) 31501026, 31771417 and 31571291NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N02 HL064278NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR059781NIAMS NIH HHS R01 AR069055NIA NIH HHS R01 AG061917NIA NIH HHS U19 AG055373NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIDDK NIH HHS R01 DK115679NIGMS NIH HHS P20 GM109036NIGMS NIH HHS R01 GM109068NIMH NIH HHS R01 MH104680NIMH NIH HHS R01 MH107354NIMH NIH HHS R01 MH118695WHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

Bone mineral density (BMD) and lean body mass (LBM) not only have a considerable heritability each, but also are genetically correlated. However, common genetic determinants shared by both traits are largely unknown. In the present study, we performed a bivariate genome-wide association study (GWAS) meta-analysis of hip BMD and trunk lean mass (TLM) in 11,335 subjects from 6 samples, and performed replication in estimated heel BMD and TLM in 215,234 UK Biobank (UKB) participants. We identified 2 loci that nearly attained the genome-wide significance (GWS, p < 5.0 × 10

Indexed as

Genetic PleiotropyGenome-Wide Association StudyAdultAgedBody CompositionBone DensityCohort StudiesEthnicityFemaleFemurGenetic HeterogeneityGenotyping TechniquesHumansMaleMiddle AgedMolecular Sequence Annotation

Identifiers

PMID32929176
PMCPMC7880826

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.