ArticleeLife2020
SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism.
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
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Who cites it
43 citing papers in PubMed, 76 citations in OpenAlex.
- Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays.bioRxiv : the preprint server for biology · 2026Article
- Subunit-specific roles of LRRC8 proteins in determining glutamate permeability of astrocytic volume-regulated anion channels.American journal of physiology. Cell physiology · 2026Article
- Endothelial LRRC8C Associates With LRRC8A and LRRC8B to Regulate Vascular Reactivity and Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2026Article
- LRRC8A: A multifaceted regulator in cancer, neurological disorders, metabolic diseases and immune modulation.Genes & diseases · 2026Review
- LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism.The Journal of physiology · 2026Article
- Endothelial LRRC8A mitigates pressure overload-induced cardiac hypertrophy by promoting coronary angiogenesis.Angiogenesis · 2025Article
- LRRC8A constitutively inhibits pain hypersensitivity in rodent models by restraining NMDA receptor activity at spinal cord synapses.Science translational medicine · 2025Article
- Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism.Science advances · 2025Article
- Excitotoxic neuronal death requires superoxide entry into neurons through volume-regulated anion channels.Science advances · 2025Article
- LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis.Blood · 2025Article
- Recent advances in the structure, function and regulation of the volume-regulated anion channels and their role in immunity.The Journal of physiology · 2025Review
- Regulation of Type 1 Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2.Diabetes · 2025Article
- The Volume-Regulated Anion Channel LRRC8 is Involved in the Initiation of Epidermal Differentiation and is Deregulated in Psoriasis.JID innovations : skin science from molecules to population health · 2025Article
- Recent insights on the impact of SWELL1 on metabolic syndromes.Frontiers in pharmacology · 2025Review
- Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy.Science advances · 2024Article
- Estrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications.Aging advances · 2024Article
- Eukaryotic cell size regulation and its implications for cellular function and dysfunction.Physiological reviews · 2024Review
- Influence of ear tags on the results of body composition analysis in mice.Animal models and experimental medicine · 2024Article
- Mechanosensing in Metabolism.Comprehensive Physiology · 2023Review
- Expression profile and bioinformatics analysis of circRNA and its associated ceRNA networks in longissimus dorsi from Lufeng cattle and Leiqiong cattle.BMC genomics · 2023Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Ashutosh KumarDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, United States.
Litao XieDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, United States.
Chau My TaDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, United States.
Antentor O HintonFraternal Order of Eagles Diabetes Research Center, Iowa City, United States.
Susheel K GunasekarDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, United States.
Rachel A MinerathFraternal Order of Eagles Diabetes Research Center, Iowa City, United States.
Karen ShenProgram in Physical Therapy and Departments of Neurology, Biomedical Engineering and Orthopedic Surgery, Washington University in St. Louis, St. Louis, United States.
Joshua M MaurerDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, United States.
Chad E GrueterFraternal Order of Eagles Diabetes Research Center, Iowa City, United States.
E Dale AbelFraternal Order of Eagles Diabetes Research Center, Iowa City, United States.ORCID 0000-0001-5290-0738
Gretchen MeyerProgram in Physical Therapy and Departments of Neurology, Biomedical Engineering and Orthopedic Surgery, Washington University in St. Louis, St. Louis, United States.
Rajan SahDepartment of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0003-1092-1244
Washington University in St. Louis · USUniversity of Iowa · USFraternal Order of Eagles · USUniversity of Central Florida · US
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MPulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3MTuning fat cell size and obesity through SWELL1R01DK106009 · NIDDK · WASHINGTON UNIVERSITY · PI SAH, RAJAN · 2016 to 2024
$3.8MInsulin Inhibition of beta-AR Signaling in the MyocardiumR01HL127764 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$2.4MMED13 Regulation of Cardiac Transcription in Obesity and HypothyroidismR01HL125436 · NHLBI · UNIVERSITY OF IOWA · PI GRUETER, CHAD E · 2015 to 2019
$1.9MCardiac Dysfunction in the Met Syndrome: Cross-talk between IR and bAR SignalingR01HL112413 · NHLBI · UNIVERSITY OF IOWA · PI ABEL, E DALE, XIANG, YANG K · 2015 to 2018
$1.6MNHLBI NIH HHS R01 HL112413NHLBI NIH HHS R01 HL125436NHLBI NIH HHS R01 HL127764NHLBI NIH HHS T32 HL007752NIAMS NIH HHS P30 AR074992NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK106009
Abstract
Maintenance of skeletal muscle is beneficial in obesity and Type 2 diabetes. Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism; however, the molecular mechanosensor remains unknown. Here, we show that SWELL1 (
Indexed as
AdiposityAnimalsCell SizeFemaleGlucoseMaleMembrane ProteinsMiceMuscle CellsMuscle, SkeletalSignal TransductionGlucoseLRRC8A protein, mouseMembrane Proteinscell biologygrowthion channelknock-out mousemouseVRAC
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What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.