Evidence mapPaperPMID 32933152Full record

ArticleInternational journal of molecular sciences2020

Dihydromyricetin Improves Endothelial Dysfunction in Diabetic Mice via Oxidative Stress Inhibition in a SIRT3-Dependent Manner.

Yu-Yun Hua, Yue Zhang, Wei-Wei Gong, Yue Ding, Jie-Ru Shen, Hua Li, Yun Chen, Guo-Liang Meng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. The Small Molecules of Plant Origin with Anti-Glioma Activity.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies.Redox report : communications in free radical research · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yu-Yun HuaDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.
Yue ZhangDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.
Wei-Wei GongDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.
Yue DingDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.
Jie-Ru ShenDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.
Hua LiDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.
Yun ChenDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.ORCID 0000-0002-8523-6543
Guo-Liang MengDepartment of Pharmacology, School of Pharmacy, Key Laboratory of Inflammation and Molecular Drug Target of Jiangsu Province, Nantong University, Nantong 226001, China.
Nantong University · CN

Funding

China Postdoctoral Science Foundation 2019T120449 and 2017M610342Jiangsu Planned Projects for Postdoctoral Research Funds 1701050ANantong University Cooperative Innovation Program of Small Molecular Compound R&D NTU2016-1Natural Science Research of Jiangsu Higher Education Institutions of China 18KJA310005Science and Technology Project of Taicang City TC2019KJFZ02Six Talent Peaks Project in Jiangsu Province 2018-WSN-062
6 · The paper itself

Abstract

Dihydromyricetin (DHY), a flavonoid component isolated from Ampelopsis grossedentata, exerts versatile pharmacological activities. However, the possible effects of DHY on diabetic vascular endothelial dysfunction have not yet been fully elucidated. In the present study, male C57BL/6 mice, wild type (WT) 129S1/SvImJ mice and sirtuin 3 (SIRT3) knockout (SIRT3

Indexed as

AnimalsAorta, ThoracicBlood GlucoseDiabetes Mellitus, ExperimentalDNADNA Copy Number VariationsDNA, MitochondrialEndothelial CellsEndothelium, VascularFlavonolsMaleMiceMice, Inbred C57BLOxidative StressReactive Oxygen SpeciesSirtuin 3Blood GlucosedihydromyricetinDNADNA, MitochondrialFlavonolsReactive Oxygen SpeciesSirt3 protein, mouseSirtuin 3Superoxide DismutaseSuperoxide Dismutase 2dihydromyricetinendothelial dysfunctionoxidative stresssirtuin 3

Identifiers

PMID32933152
PMCPMC7555401
OpenAlexW3086229853

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.