Evidence map›Paper›PMID 32936716›Full record

ArticleCell cycle (Georgetown, Tex.)2020

LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis.

Ganghua Yang, Lijing Zhou, Qinhong Xu, Fandi Meng, Yong Wan, Xiankui Meng, Lin Wang, Lei Zhang

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ganghua YangDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
Lijing ZhouDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
Qinhong XuDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
Fandi MengDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
Yong WanDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
Xiankui MengDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
Lin WangDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
Lei ZhangDepartment of Geriatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death, and radiotherapy is currently one of the main treatments. Long non-coding RNAs (lncRNAs) are associated with the radiosensitivity and tumorigenesis of HCC. However, the role and molecular mechanism of potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) in HCC are still unclear. The relative expression of KCNQ1OT1, microRNA-146a-5p (miR-146a-5p) and alkaline ceramidase 3 (ACER3) was quantified by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. Clonogenic assay was used to assess the radiosensitivity of cells. Cell apoptosis and metastasis were evaluated by flow cytometry and transwell assays, respectively. The protein levels of apoptosis markers, metastasis markers and ACER3 were detected by western blot (WB) analysis. The relationship between miR-146a-5p and KCNQ1OT1 or ACER3 was determined by dual-luciferase reporter assay. Additionally, animal experiments were carried out to explore the effect of KCNQ1OT1 silencing on HCC tumor growth

Indexed as

Radiation ToleranceAlkaline CeramidaseAnimalsApoptosisCarcinoma, HepatocellularCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMice, Inbred BALB CMice, NudeMicroRNAsNeoplasm InvasivenessPotassium Channels, Voltage-GatedACER3 protein, humanAlkaline CeramidaseKCNQ1OT1 long non-coding RNA, humanMicroRNAsMIRN146 microRNA, humanPotassium Channels, Voltage-GatedACER3Hepatocellular carcinomaKCNQ1OT1miR-146a-5pradiosensitivitytumorigenesis

Identifiers

PMID32936716
PMCPMC7553536
OpenAlexW3087065656

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.