Evidence map›Paper›PMID 32937071›Full record

ReviewChemical reviews2020

Emulating Human Tissues and Organs: A Bioprinting Perspective Toward Personalized Medicine.

Ana Clotilde Fonseca, Ferry P W Melchels, Miguel J S Ferreira, Samuel R Moxon, Geoffrey Potjewyd, Tim R Dargaville, Susan J Kimber, Marco Domingos

Open access · hybridAbstract readReview
In one paragraph

Review in Chemical reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 111 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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  11. Bioprinted Organoids: An Innovative Engine in Biomedicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Branding a New Technological Outlook for Future Orthopaedics.Bioengineering (Basel, Switzerland) · 2025
    Review
  16. Review
  17. Personalized Kirigami Strain Sensors for in vivo Applications.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Ana Clotilde FonsecaCentre for Mechanical Engineering, Materials and Processes, Department of Chemical Engineering, University of Coimbra, Rua Sílvio Lima-Polo II, 3030-790 Coimbra, Portugal.ORCID 0000-0002-7145-2472
Ferry P W MelchelsInstitute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, U.K.ORCID 0000-0002-5881-837X
Miguel J S FerreiraDepartment of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, U.K.ORCID 0000-0001-7529-6553
Samuel R MoxonDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, U.K.ORCID 0000-0002-9819-9622
Geoffrey PotjewydDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, U.K.ORCID 0000-0002-1970-9429
Tim R DargavilleInstitute of Health and Biomedical Innovation, Science and Engineering Faculty, Queensland University of Technology, Queensland 4001, Australia.ORCID 0000-0003-4665-9508
Susan J KimberDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, U.K.ORCID 0000-0002-0568-6342
Marco DomingosDepartment of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, U.K.ORCID 0000-0002-6693-790X
University of Manchester · GBHeriot-Watt University · GBQueensland University of Technology · AUUniversity of Coimbra · PTWellcome Centre for Cell-Matrix Research · GB

Funding

Arthritis Research UK R20786Biotechnology and Biological Sciences Research Council BB/D014530/1Medical Research Council MR/L004992/1Medical Research Council MR/M017354/1Medical Research Council MR/S002553/1
6 · The paper itself

Abstract

The lack of in vitro tissue and organ models capable of mimicking human physiology severely hinders the development and clinical translation of therapies and drugs with higher in vivo efficacy. Bioprinting allow us to fill this gap and generate 3D tissue analogues with complex functional and structural organization through the precise spatial positioning of multiple materials and cells. In this review, we report the latest developments in terms of bioprinting technologies for the manufacturing of cellular constructs with particular emphasis on material extrusion, jetting, and vat photopolymerization. We then describe the different base polymers employed in the formulation of bioinks for bioprinting and examine the strategies used to tailor their properties according to both processability and tissue maturation requirements. By relating function to organization in human development, we examine the potential of pluripotent stem cells in the context of bioprinting toward a new generation of tissue models for personalized medicine. We also highlight the most relevant attempts to engineer artificial models for the study of human organogenesis, disease, and drug screening. Finally, we discuss the most pressing challenges, opportunities, and future prospects in the field of bioprinting for tissue engineering (TE) and regenerative medicine (RM).

Indexed as

BioprintingPrecision MedicinePrinting, Three-DimensionalTissue EngineeringHumansPolymersTissue ScaffoldsPolymers

Identifiers

PMID32937071
PMCPMC7645917
OpenAlexW3087281011

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.