Evidence map›Paper›PMID 32939435›Full record

ArticleJournal of the Endocrine Society2020

Multisystem Progeroid Syndrome With Lipodystrophy, Cardiomyopathy, and Nephropathy Due to an

Iram Hussain, Ruilin Raelene Jin, Howard B A Baum, Jerry R Greenfield, Sophie Devery, Chao Xing, Robert A Hegele, Barbara G Carranza-Leon, Macrae F Linton, Frank Vuitch and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Lipodystrophic Laminopathies: From Dunnigan Disease to Progeroid Syndromes.International journal of molecular sciences · 2024
    Review
  6. Lipodystrophy-associated progeroid syndromes.Hormones (Athens, Greece) · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Iram HussainDivision of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-2723-0490
Ruilin Raelene JinDepartment of Clinical Genomics, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.ORCID 0000-0002-7255-5588
Howard B A BaumDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-7511-8001
Jerry R GreenfieldDepartment of Endocrinology, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.
Sophie DeveryDepartment of Clinical Genomics, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.ORCID 0000-0002-1904-499X
Chao XingEugene McDermott Center for Human Growth and Development, Department of Population and Data Sciences, and Department of Bioinformatics, UT Southwestern Medical Center, Dallas, Texas, USA.
Robert A HegeleDepartment of Medicine, Western University, London, Ontario, Canada.ORCID 0000-0003-2861-5325
Barbara G Carranza-LeonDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Macrae F LintonDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Frank VuitchDepartment of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.
Kathy H C WuDepartment of Clinical Genomics, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.
Débora Rossi PreciosoPhysician Sarah Network of Rehabilitation Hospitals (Unit Belo Horizonte), Internal Medicine, Preoperative Outpatient Clinic, Osteometabolism, Belo Horizonte, Brazil.
Junko OshimaDepartment of Pathology, University of Washington, Seattle, Washington, USA.
Anil K AgarwalDivision of Nutrition and Metabolic Diseases, Department of Internal Medicine, and Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas, USA.
Abhimanyu GargDivision of Nutrition and Metabolic Diseases, Department of Internal Medicine, and Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-7209-6986
Southwestern Medical Center · USSt Vincent's Hospital Sydney · AUVanderbilt University Medical Center · USSarah Network of Rehabilitation Hospitals · BRUniversity of Washington · USWestern University · CA

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
NORTH AND CENTRAL TEXAS CTSA FOR PEDIATRIC RESEARCHUL1RR024982 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2007 to 2011
$27.9M
Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVIES, SEAN STEPHEN · 2014 to 2025
$24.7M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Genetic and Metabolic Basis of Familial LipodystrophiesR01DK105448 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Abhimanyu Garg · 2015 to 2026
$6.5M
International Registry of Werner SyndromeR01CA210916 · NCI · UNIVERSITY OF WASHINGTON · PI JUNKO OSHIMA · 2016 to 2026
$3.8M
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR001105NCATS NIH HHS UL1 TR002240NCI NIH HHS R01 CA210916NCRR NIH HHS UL1 RR024982NHLBI NIH HHS P01 HL116263NIDDK NIH HHS R01 DK105448
6 · The paper itself

Abstract

backgroundPathogenic variants in lamin A/C (

methodsWe report 6 new patients with a heterozygous

resultsOf the total 17 patients, all 14 adults with the heterozygous

conclusionsThe heterozygous

Indexed as

cardiomyopathydiabetes mellitusfocal segmental glomerulosclerosislamin A/Clipodystrophyprogeroid syndrome

Identifiers

PMID32939435
PMCPMC7485795
OpenAlexW3046204727

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.