Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

1. Comprehensive review of safety in Experimental Human Pneumococcal Challenge.PloS one · 2023
   Pooled it
2. Natural Carriage of Streptococcus pneumoniae Is Associated With Increased Experimental Pneumococcal Carriage but Reduced Conjugate Vaccine Efficacy in a Human Challenge Model.The Journal of infectious diseases · 2025
   Trial
3. Indirect Effects in Health Economic Models of Vaccines: Should We Include Them, and How Do We Model Them?Applied health economics and health policy · 2026
   Review
4. Acceptability of advanced Controlled Human Infection Models: The case of a pneumococcal challenge in people living with HIV and mycobacterial challenge with Bacillus Calmette Guerin in Malawi.PLOS global public health · 2026
   Article
5. Kinetic profile and mucosal capsular polysaccharide IgG responses to serotype 3 pneumococcus in the adult oropharynx following an experimental human challenge.Frontiers in microbiology · 2026
   Article
6. Understanding the interaction of upper respiratory tract infection with respiratory syncytial virus and Streptococcus pneumoniae using a human challenge model: a multicenter, randomized controlled study protocol.PloS one · 2025
   Article
7. Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis.Frontiers in immunology · 2025
   Review
8. Symptoms and adverse events in controlled human infection models.Frontiers in medicine · 2025
   Review
9. Serological Profiling of Pneumococcal Proteins Reveals Unique Patterns of Acquisition, Maintenance, and Waning of Antibodies Throughout Life.The Journal of infectious diseases · 2024
   Article
10. Inflammation of the nasal mucosa is associated with susceptibility to experimental pneumococcal challenge in older adults.Mucosal immunology · 2024
    Article
11. Considerations in planning a controlled human infection model in at-risk groups in sub-Saharan Africa: the case for pneumococcal challenge in people living with HIV in Malawi and a report of stakeholder consultation.Wellcome open research · 2024
    Article
12. Baseline Pneumococcal IgG Levels and Response to 23-Valent Pneumococcal Polysaccharide Vaccine among Adults from Beijing, China.Vaccines · 2023
    Article
13. Complicated Invasive Pneumococcal Meningitis: Highlighting the Value of Implementing New Pneumococcal Vaccines.Cureus · 2023
    Article
14. Polysaccharide and conjugate vaccines toScience translational medicine · 2022
    Article
15. Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2).BMJ open · 2022
    Article
16. The drop in reported invasive pneumococcal disease among adults during the first COVID-19 wave in the Netherlands explained.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Article
17. The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash.Scientific reports · 2021
    Article
18. Experimental Model for Studies of Pneumococcal Colonization in Older Adults.American journal of respiratory and critical care medicine · 2021
    Article
19. Insights Into the Effects of Mucosal Epithelial and Innate Immune Dysfunction in Older People on Host Interactions WithFrontiers in cellular and infection microbiology · 2021
    Review
20. Serum levels of anti-PspA and anti-PspC IgG decrease with age and do not correlate with susceptibility to experimental human pneumococcal colonization.PloS one · 2021
    Article

Corrections and comments

• Commented on by
  Experimental Model for Studies of Pneumococcal Colonization in Older Adults.2021

Authors and funding

29 authors at 3 institutions in 2 countries.

Funding

Abstract

PubMed holds no abstract for this paper.

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