Evidence map›Paper›PMID 32945661›Full record

ArticleBiochemistry2020

Nucleotide Excision Repair, XPA-1, and the Translesion Synthesis Complex, POLZ-1 and REV-1, Are Critical for Interstrand Cross-Link Repair in

Sinae Oh, Woori Bae, Mohammad A Alfhili, Myon Hee Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Sinae OhDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 03772 Seoul, South Korea.
Woori BaeDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, 03772 Seoul, South Korea.
Mohammad A AlfhiliChair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.ORCID 0000-0002-3095-9154
Myon Hee LeeDepartment of Internal Medicine, Hematology/Oncology Division, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, United States.ORCID 0000-0001-9020-2391
Yonsei University · KREast Carolina University · USKing Saud University · SA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Action Mechanisms of Resveratrol in Somatic Longevity and Reproductive SystemR15AG060373 · NIA · EAST CAROLINA UNIVERSITY · PI LEE, MYON HEE · 2018 to 2019
$459k
NIA NIH HHS R15 AG060373NIH HHS P40 OD010440
6 · The paper itself

Abstract

Interstrand cross-links (ICLs) are adducts of covalently linked nucleotides in opposing DNA strands that obstruct replication and prime cells for malignant transformation or premature cell death. ICLs may be caused by alkylating agents or ultraviolet (UV) irradiation. These toxic lesions are removed by diverse repair mechanisms such as the Fanconi anemia (FA) pathway, nucleotide excision repair (NER), translesion synthesis (TLS), and homologous recombination (HR). In mammals, the xeroderma pigmentosum group F (XP-F) protein participates in both the FA pathway and NER, while DNA polymerase ζ (POLZ-1) and REV-1 mediate TLS. Nevertheless, little is known regarding the genetic determinants of these pathways in ICL repair and damage tolerance in germ cells. In this study, we examined the sensitivity of

Indexed as

DNA RepairAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNADNA DamageDNA-Directed DNA PolymeraseDNA HelicasesTrioxsalenUltraviolet RaysXeroderma Pigmentosum Group A ProteinCaenorhabditis elegans ProteinsDNADNA-Directed DNA PolymeraseDNA HelicasesDNA polymerase zetaTrioxsalenXeroderma Pigmentosum Group A ProteinXPA-1 protein, C elegansXPF-1 protein, C elegans

Identifiers

PMID32945661
PMCPMC7590238
OpenAlexW3087448268

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.