ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
Development and Validation of 2 Composite Aging Measures Using Routine Clinical Biomarkers in the Chinese Population: Analyses From 2 Prospective Cohort Studies.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed.
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- Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population-Based Study and Gut Microbiota Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The impact of cumulative obesity and genetic susceptibility on biological aging in Chinese older adults.GeroScience · 2026Article
- Association between adverse childhood experiences and accelerated aging of middle-aged and older Chinese: based on the China health and retirement longitudinal study.BMC public health · 2026Observational
- Construction and Validation of Plasma Protein-Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles.Aging cell · 2026Article
- The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank.The journal of nutrition, health & aging · 2026Article
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- Impact of body roundness index on cognitive decline and cognitive impairment in middle-aged and older adults ≥ 45 years: mediating role of biological aging.Scientific reports · 2026Article
- Accelerated biological aging and underlying epigenetic modification mediated the association between obesity and asthma.Clinical epigenetics · 2026Article
- Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.Cardiovascular diabetology · 2026Article
- Associations of Biological Age and Heart Age Accelerations With New-Onset Stroke in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From a Chinese Longitudinal Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
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- Sex-Specific Biological Aging-Related Lipidomic Profiles Mediate the Impact of Urinary Polycyclic Aromatic Hydrocarbon Exposures on Cognitive Function in Healthy Older Adults.Environment & health (Washington, D.C.) · 2026Article
- Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank.Stroke and vascular neurology · 2026Article
- Association of various insulin resistance surrogate indices with aging acceleration and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: insights from CHARLS 2011-2020 data.Cardiovascular diabetology · 2026Article
- Biological age acceleration and interaction with genetic predisposition in the risk of type 2 diabetes and coronary artery disease.GeroScience · 2026Article
- Biological aging, a mediator between smoking and chronic obstructive pulmonary disease: evidence from a hospital-based cohort study in China.BMC pulmonary medicine · 2026Article
- Heatwave Exposure Accelerates Biological Aging via Metabolic Dysregulation.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Association of biological age acceleration with cardiovascular disease and premature mortality: a population-based prospective cohort study.Frontiers in public health · 2026Article
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Abstract
backgroundThis study aimed to: (i) develop 2 composite aging measures in the Chinese population using 2 recent advanced algorithms (the Klemera and Doubal method and Mahalanobis distance); and (ii) validate the 2 measures by examining their associations with mortality and disease counts.
methodsBased on data from the China Nutrition and Health Survey (CHNS) 2009 wave (N = 8119, aged 20-79 years, 53.5% women), a nationwide prospective cohort study of the Chinese population, we developed Klemera and Doubal method-biological age (KDM-BA) and physiological dysregulation (PD, derived from Mahalanobis distance) using 12 biomarkers. For the validation analysis, we used Cox proportional hazard regression models (for mortality) and linear, Poisson, and logistic regression models (for disease counts) to examine the associations. We replicated the validation analysis in the China Health and Retirement Longitudinal Study (CHARLS, N = 9304, aged 45-99 years, 53.4% women).
resultsBoth aging measures were predictive of mortality after accounting for age and gender (KDM-BA, per 1-year, hazard ratio [HR] = 1.14, 95% confidence interval [CI] = 1.08, 1.19; PD, per 1-SD, HR = 1.50, 95% CI = 1.33, 1.69). With few exceptions, these mortality predictions were robust across stratifications by age, gender, education, and health behaviors. The 2 aging measures were associated with disease counts both cross-sectionally and longitudinally. These results were generally replicable in CHARLS although 4 biomarkers were not available.
conclusionsWe successfully developed and validated 2 composite aging measures-KDM-BA and PD, which have great potentials for applications in early identifications and preventions of aging and aging-related diseases in China.
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