ArticleScience immunology2020
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 62 citations in OpenAlex.
- PD-1 regulates CD4Nature communications · 2026Article
- Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Brain Immune Cell Composition in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy After Natalizumab: An Immunohistochemical Cohort Study.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- PD-1 Inhibits CD4+ TRM-Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Living rent free in your head: resident memory T cells.ImmunoHorizons · 2026Review
- HIF-1αImmunity · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Evolving role of CD8Frontiers in immunology · 2026Review
- CXCR4 and CXCR6 dually limit T cell entry into the polyomavirus-infected brain.Journal of neuroinflammation · 2025Article
- CXCR6 promotes dermal CD8bioRxiv : the preprint server for biology · 2025Article
- Dural Tregs driven by astrocytic IL-33 mitigate depression through the EGFR signals in mPFC neurons.Cell death and differentiation · 2025Article
- Chronic IL-21 drives neuroinflammation and promotes lipid accumulation in microglia.Immunity & ageing : I & A · 2025Article
- The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney.PLoS pathogens · 2025Article
- Keeping it local: how CD8 TRMs regulate viral and cancer immunity.Frontiers in immunology · 2025Review
- Lung-resident lymphocytes and their roles in respiratory infections and chronic respiratory diseases.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure.World journal of clinical cases · 2024Review
- Protective function and differentiation cues of brain-resident CD8+ T cells during surveillance of latentProceedings of the National Academy of Sciences of the United States of America · 2024Article
- IL-21, not IL-17A, exacerbates murine primary biliary cholangitis.Clinical and experimental immunology · 2024Article
- Cytokines in Follicular Helper T Cell Biology in Physiologic and Pathologic Conditions.Immune network · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Heather M RenDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-0220-6286
Elizabeth M KolawoleDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3138-0037
Mingqiang RenConsortium for Health and Military Performance, Department of Military & Emergency Medicine, Uniformed Services University, Bethesda, MD 20814, USA.ORCID 0000-0002-1561-7711
Ge JinDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA 17033, USA.
Colleen S Netherby-WinslowDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-5676-768X
Quinn WadeDepartment of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-9328-8722
ShwetankDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-5069-603X
Ziaur S M RahmanDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA 17033, USA.
Brian D EvavoldDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-3561-3494
Aron E LukacherDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA 17033, USA. alukacher@pennstatehealth.psu.edu.ORCID 0000-0002-7969-2841
Penn State Milton S. Hershey Medical Center · USUniversity of Utah · USUnifor · NO
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6MCD8 T cell antigen recognition during chronic infectionR01AI147641 · NIAID · UNIVERSITY OF UTAH · PI EVAVOLD, BRIAN D · 2020 to 2024
$3.3MA Mouse Model to Define Immunovirologic Determinants of Polyomavirus CNS DiseaseR01NS088367 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LUKACHER, ARON ELIOT · 2014 to 2021
$2.8MPathogenesis of Mouse Polyomavirus-associated CNS DemyelinationR01NS092662 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LUKACHER, ARON ELIOT · 2016 to 2022
$2.1MEvolution of CD8+ TCR affinity during chronic viral infectionR01AI096879 · NIAID · EMORY UNIVERSITY · PI EVAVOLD, BRIAN D · 2012 to 2016
$2.1M"Perturbation of peripheral B cell tolerance by the lupus susceptibility loci"R01AI091670 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI RAHMAN, ZIAUR · 2011 to 2015
$1.9MUniv of Utah Cell Sorter for Flow Cytometry CoreS10RR026802 · NCRR · UNIVERSITY OF UTAH · PI GREEN, WAYNE FRANCIS · 2010 to 2010
$500kGeneration of CNS-resident memory T cells and mechanisms of glial cell dysfunction during polyomavirus encephalitisF32NS106730 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI NETHERBY-WINSLOW, COLLEEN S · 2018 to 2020
$136kMechanisms of Cellular and Humoral Immune Evasion and Subsequent Polyomavirus EncephalitisF31AI142997 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI REN, HEATHER MARIE · 2019 to 2019
$25kNCI NIH HHS P30 CA042014NCRR NIH HHS S10 RR026802NIAID NIH HHS F31 AI142997NIAID NIH HHS R01 AI091670NIAID NIH HHS R01 AI096879NIAID NIH HHS R01 AI147641NINDS NIH HHS F32 NS106730NINDS NIH HHS R01 NS088367NINDS NIH HHS R01 NS092662
Abstract
Development of tissue-resident memory (T
Indexed as
PolyomavirusAnimalsBrainCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCytokinesInterleukin-21InterleukinsMice, Inbred C57BLMice, KnockoutPolyomavirus InfectionsSpleenTumor Virus InfectionsCytokinesInterleukin-21Interleukins
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.