Evidence map›Paper›PMID 32950989›Full record

Trial reportObesity facts2020

Weight Loss, Dietary Preferences, and Reduction in the Sense of Smell with the Use of a Novel Nasal Device.

Dror Dicker, Adva Beck, Arie Markel, Dana Marcovicu, Salim Mazzawi, Miri Sarid, Elhanan Greenberg, Richard L Atkinson

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity facts, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Smell, taste and food habits changes along body mass index increase: an observational study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Dror DickerInternal Medicine D and Obesity Clinic, Hasharon Hospital, Rabin Medical Center, Petach-Tikva, Israel, daniel3@013.net.
Adva BeckBeck Medical, Givat-Ada, Israel.
Arie MarkelHaemek Medical Center, Afula, Israel.
Dana MarcovicuInternal Medicine D and Obesity Clinic, Hasharon Hospital, Rabin Medical Center, Petach-Tikva, Israel.
Salim MazzawiOtolaryngology Head and Neck Surgery, Haemek Medical Center, Rappaport School of Medicine, Technion, Israel.
Miri SaridWestern Galilee College, Akko, Israel.
Elhanan GreenbergBeck Medical, Givat-Ada, Israel.
Richard L AtkinsonVirginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Rabin Medical Center · ILEmek Medical Center · ILVirginia Commonwealth University · USWestern Galilee College · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExposure to food odors are known to increase food intake. Olfaction declines from age 50 years.

objectiveWe examined changes in the sense of smell, body weight, food preferences, and parameters of metabolic status, following the use of a specially designed nasal device.

methodsThis is a randomized, placebo-controlled study. Participants wore a nasal device (soft silicone insert) for 5-12 h daily (device group) or inserted 2 drops of normal saline into each nostril daily (control group). Follow-up visits occurred every 2 weeks. All participants were given a 500 kcal/day reduced diet and instructed not to change their regular physical activity. Weight, food preferences, olfactory sensitivity, and blood tests were performed at baseline and after 12 weeks.

resultsOf 156 participants, 65 (42%) completed the study. Sense of smell decreased in the device group (from 6.4 ± 0.9 to 4.4 ± 1.5, on a scale of 0-7, p < 0.001), and did not change in the control group. Weight loss decreased by 6.6 ± 3.7% (p = 0.001) and by 5.7 ± 3.5% (p = 0.001) in the respective groups (between-group difference, p > 0.05). Among participants aged ≤50 years, weight loss was greater in the device than in the control group (7.7 ± 4.2% vs. 4.1 ± 2.9%, p = 0.02). Insulin level and the homeostatic model assessment of insulin resistance (HOMA-IR) were significantly reduced in the device group (p = 0.02 and p = 0.01, respectively), but not in the control group. Food preferences for sugar (p < 0.02), sweet beverages (p < 0.001), and artificial sweeteners (p < 0.02) were significantly reduced in the device group compared to the control group.

conclusionsThe use of a novel self-administrated nasal device led to reduced olfactory sensitivity, improved insulin sensitivity, weight loss, and lesser preference for sweets in adults aged ≤50 years.

Indexed as

Food PreferencesSmellWeight LossAdolescentAdultAgedBody WeightDietFemaleHumansMaleMiddle AgedNoseYoung AdultDietary preferencesNasal deviceObesityOlfactory sensitivitySense of smell

Identifiers

PMID32950989
PMCPMC7670359
OpenAlexW3087168404

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.