SynthesisNeuropsychology review2021
A Systematic Review of the Application of Functional Near-Infrared Spectroscopy to the Study of Cerebral Hemodynamics in Healthy Aging.
Synthesis in Neuropsychology review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Activation of Brain Regions Associated with Working Memory and Inhibitory Control in Patients with Attention-Deficit/Hyperactivity Disorder in Functional Near-Infrared Spectroscopy: A Systematic Review.Current medical imaging · 2023Pooled it
- The choice stepping reaction task: how prefrontal network topology reconfigures in aging and dementia.GeroScience · 2026Article
- Oxygenaging: A Physiological Framework for Geroscience.Aging cell · 2026Review
- Physiological Responses to Prior Verbal Notice Before Passive Postural Change: A Randomized Crossover Exploratory Study of Circulatory and Autonomic Dynamics.Healthcare (Basel, Switzerland) · 2026Article
- Cerebral oxygenation responses to obstructive sleep apnea in cognitively normal older adults: a study using simultaneous polysomnography and functional near-infrared spectroscopy.Scientific reports · 2025Article
- Functional Near-Infrared Spectroscopy in Schizophrenia Research: Progress, Challenges, and Future Directions.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- The relationship between fractional amplitude of low-frequency fluctuations (fALFF) and the severity of neglect in patients with unilateral spatial neglect (USN) after stroke: A functional near-infrared spectroscopy study.IBRO neuroscience reports · 2025Article
- Application of Near-Infrared Spectroscopy in Early Detection of Antidepressant Treatment Efficacy in Major Depressive Disorder: A Longitudinal Study.Actas espanolas de psiquiatria · 2025Article
- Important role of the right hemisphere in post-stroke cognitive impairment: a functional near-infrared spectroscopy study.Neurophotonics · 2025Article
- The Physiologic Complexity of Prefrontal Oxygenation Dynamics Is Associated With Age and Executive Function: An Exploratory Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Investigating cortical hypoxia in multiple sclerosis via time-domain near-infrared spectroscopy.Annals of clinical and translational neurology · 2024Article
- Gender Differences in Prefrontal Cortex Response to Negative Emotional Stimuli in Drivers.Brain sciences · 2024Article
- The phase coherence of the neurovascular unit is reduced in Huntington's disease.Brain communications · 2024Article
- Does Playing Mahjong Benefit Older Individuals? A Scoping Review.The journal of prevention of Alzheimer's disease · 2024Article
- Effects of endurance exercise on physiologic complexity of the hemodynamics in prefrontal cortex.Neurophotonics · 2024Article
- Is age or cardiovascular comorbidity the main predictor of reduced cerebrovascular pressure reactivity in older patients with traumatic brain injury?Brain & spine · 2024Article
- Prefrontal hemodynamic features of older adults with preserved visuospatial working memory function.GeroScience · 2023Article
- Novel automaticity index reveals a cognitive ability-related decline in gait automaticity during dual-task walking.bioRxiv : the preprint server for biology · 2023Article
- Safety and feasibility of transcutaneous vagus nerve stimulation in mild cognitive impairment: VINCI-AD study protocol.BMC neurology · 2023Article
- Stroke analysis and recognition in functional near-infrared spectroscopy signals using machine learning methods.Biomedical optics express · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies have shown that healthy aging is associated with functional brain deterioration that preferentially affects the prefrontal cortex. This article reviews the application of an alternative method, functional near-infrared spectroscopy (fNIRS), to the study of age-related changes in cerebral hemodynamics and factors that influence cerebral hemodynamics in the elderly population. We conducted literature searches in PudMed and PsycINFO, and selected only English original research articles that used fNIRS to study healthy individuals with a mean age of ≥ 55 years. All articles were published in peer-reviewed journals between 1977 and May 2019. We synthesized 114 fNIRS studies examining hemodynamic changes that occurred in the resting state and during the tasks of sensation and perception, motor control, semantic processing, word retrieval, attentional shifting, inhibitory control, memory, and emotion and motivation in healthy older adults. This review, which was not registered in a registry, reveals an age-related reduction in resting-state cerebral oxygenation and connectivity in the prefrontal cortex. It also shows that aging is associated with a reduction in functional hemispheric asymmetry and increased compensatory activity in the frontal lobe across multiple task domains. In addition, this article describes the beneficial effects of healthy lifestyles and the detrimental effects of cardiovascular disease risk factors on brain functioning among nondemented older adults. Limitations of this review include exclusion of gray and non-English literature and lack of meta-analysis. Altogether, the fNIRS literature provides some support for various neurocognitive aging theories derived from task-based PET and fMRI studies. Because fNIRS is relatively motion-tolerant and environmentally unconstrained, it is a promising tool for fostering the development of aging biomarkers and antiaging interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.