ArticleBrain and behavior2020
The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 22 citations in OpenAlex.
- Multidimensional dataset for cognitive assessment, sMRI, and rsfMRI in common benign epileptic children.Scientific data · 2025Article
- Decision-making impairments in epilepsy: behavioral and EEG evidence of event-related potential.Frontiers in neuroscience · 2025Article
- The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks.Frontiers in psychiatry · 2025Article
- Structure-function interrelationships and associated neurotransmitter profiles in drug-naïve benign childhood epilepsy with central-temporal spikes patients.European radiology · 2025Article
- Impact of interictal epileptiform discharges on brain network in self-limited epilepsy with centrotemporal spikes: A magnetoencephalography study.Brain and behavior · 2023Article
- Neurocognitive and psychological comorbidities in patients with self-limited centrotemporal spike epilepsy. A case-control study.Revista de neurologia · 2023Article
- Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes.Life (Basel, Switzerland) · 2023Article
- Changes in functional connectivity in newly diagnosed self-limited epilepsy with centrotemporal spikes and cognitive impairment: An MEG study.Brain and behavior · 2022Article
- Relationship between brain activity, cognitive function, and sleep spiking activation in new-onset self-limited epilepsy with centrotemporal spikes.Frontiers in neurology · 2022Article
- Frequency-Dependent Dynamics of Functional Connectivity Networks During Seizure Termination in Childhood Absence Epilepsy: A Magnetoencephalography Study.Frontiers in neurology · 2021Article
- Impact of Antiepileptic Drugs on Cognition and Neuromagnetic Activity in Childhood Epilepsy With Centrotemporal Spikes: A Magnetoencephalography Study.Frontiers in human neuroscience · 2021Article
- The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes.Brain and behavior · 2020Article
- Alleviation of depression-like behavior in a cystic fibrosis mouse model by Hdac6 depletion.Scientific reports · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionThis study was aimed to explore the relationship between neural network changes in newly diagnosed children with Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) and cognitive impairment.
methodsChildren's cognition was evaluated using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Magnetoencephalographic (MEG) data of 18 healthy children and 22 BECTS patients were recorded in order to construct a functional connectivity (FC) network, which was quantified by graph theory (GT).
resultsThe mean age of the control group was 7.94 ± 1.89 years, and the mean age of BECTS patients was 8.14 ± 1.73 years. Our results show that the WISC-IV index scores in the BECTS group were significantly lower than those in the control group. Besides, the FC network pattern of BECTS patients changed significantly in the 12-30, 30-80, and 250-500 Hz frequency band. The local functional connections between posterior cingulate cortex (PCC) and frontal lobe varied significantly in 12-30, 80-250, and 250-500 Hz. Our GT analysis shows that the connection strength of BECTS patients increases significantly in the 12-30 Hz frequency band, the path length decreases significantly in the 12-30 Hz and 30-80 Hz frequency bands, with the clustering coefficient decreasing significantly in the 12-30 Hz, 30-80 Hz, and 250-500 Hz frequency bands. Correlation analysis showed that the full-scale IQ (FSIQ) was positively correlated with the 12-30 Hz clustering coefficient, verbal comprehension index (VCI) was positively correlated with the 250-500 Hz clustering coefficient, perceptual reasoning index (PRI) was positively correlated with the 12-30 Hz clustering coefficient, and perceptual reasoning index (PSI) was negatively correlated with the 12-30 Hz path length.
conclusionThere is a trend of cognitive impairment in patients with early BECTS. This trend of cognitive impairment in early BECTS children may be related to the changes in the FC network pattern.
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