Evidence map›Paper›PMID 32962107›Full record

ReviewInternational journal of molecular sciences2020

Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage.

Pavle Andjus, Maja Kosanović, Katarina Milićević, Mukesh Gautam, Seppo J Vainio, Denis Jagečić, Elena N Kozlova, Augustas Pivoriūnas, Juan-Carlos Chachques, Mirena Sakaj and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Apple-Derived Vesicles Orchestrate Bone Regeneration:International journal of molecular sciences · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 8 countries.

Pavle AndjusCenter for Laser Microscopy, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Maja KosanovićInstitute for the Application of Nuclear Energy, INEP, University of Belgrade, 11080 Belgrade, Serbia.
Katarina MilićevićCenter for Laser Microscopy, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.
Mukesh GautamFeinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Seppo J VainioFaculty of Biochemistry and Molecular Medicine, Disease Networks Research Unit, InfoTech Oulu, Kvantum Institute, University of Oulu, Borealis Biobank of Northern Finland, Univ. Oulu Hospital, FI-90014 Oulu, Finland.
Denis JagečićLaboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, HR-10000 Zagreb, Croatia.
Elena N KozlovaLaboratory of Regenerative Neurobiology, Department of Neuroscience, Uppsala University, 75237 Uppsala, Sweden.
Augustas PivoriūnasDepartment of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, LT-01001 Vilnius, Lithuania.
Juan-Carlos ChachquesLaboratory of Biosurgical Research (Alain Carpentier Foundation), Pompidu Hospital, University Paris Descartes, 75015 Paris, France.
Mirena SakajDepartment of Molecular Science and Nanosystems, Ca' Foscari University of Venice, 30100 Venice, Italy.
Giulia BrunelloDepartment of Neurosciences, University of Padova, 35128 Padova, Italy.
Dinko MitrecicLaboratory for Stem Cells, Croatian Institute for Brain Research, University of Zagreb School of Medicine, HR-10000 Zagreb, Croatia.
Barbara ZavanDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-4779-4456
University of Belgrade · RSUniversity of Zagreb · HRBorealis (Finland) · FICa' Foscari University of Venice · ITDélégation Paris 5 · FRNorthwestern University · USState Research Institute Centre for Innovative Medicine · LTUniversity of Ferrara · ITUniversity of Padua · ITUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) have recently attracted a great deal of interest as they may represent a new biosignaling paradigm. According to the mode of biogenesis, size and composition, two broad categories of EVs have been described, exosomes and microvesicles. EVs have been shown to carry cargoes of signaling proteins, RNA species, DNA and lipids. Once released, their content is selectively taken up by near or distant target cells, influencing their behavior. Exosomes are involved in cell-cell communication in a wide range of embryonic developmental processes and in fetal-maternal communication. In the present review, an outline of the role of EVs in neural development, regeneration and diseases is presented. EVs can act as regulators of normal homeostasis, but they can also promote either neuroinflammation/degeneration or tissue repair in pathological conditions, depending on their content. Since EV molecular cargo constitutes a representation of the origin cell status, EVs can be exploited in the diagnosis of several diseases. Due to their capability to cross the blood-brain barrier (BBB), EVs not only have been suggested for the diagnosis of central nervous system disorders by means of minimally invasive procedures, i.e., "liquid biopsies", but they are also considered attractive tools for targeted drug delivery across the BBB. From the therapeutic perspective, mesenchymal stem cells (MSCs) represent one of the most promising sources of EVs. In particular, the neuroprotective properties of MSCs derived from the dental pulp are here discussed.

Indexed as

Amyotrophic Lateral SclerosisAxonsBlood-Brain BarrierCell CommunicationCell-Derived MicroparticlesDental PulpExosomesFemaleHumansMicroRNAsNervous System DiseasesNeural Stem CellsPlacentaPregnancyRegenerationMicroRNAsdrug deliveryexosomesmicrovesiclesmiRNAneurological disordersneuronal developmentstem cellstheragnostic blood–brain barrier

Identifiers

PMID32962107
PMCPMC7555813
OpenAlexW3087167561

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.