ArticleCanadian journal of kidney health and disease2020
Frailty and the Kidney Transplant Wait List: Protocol for a Multicenter Prospective Study.
Article in Canadian journal of kidney health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Understanding frailty across the kidney transplant continuum: a comprehensive systematic review of recent evidence.International urology and nephrology · 2026Pooled it
- "You Gotta Keep Climbing That Mountain to Reach the Goal": Perspectives of Transplant Waitlisted Dialysis Patients. A Qualitative Study.Kidney medicine · 2026Article
- Reduced Functional Status among Kidney Transplant Recipients over Time and Associated Risks Post-Transplant.Clinical transplantation · 2025Article
- Assessing Cognition in Kidney Failure Using Virtual Reality Technology: A Clinical Research Protocol.Canadian journal of kidney health and disease · 2025Article
- Characterizing adult rehabilitation programs for solid organ transplant candidates and recipients across Canada.Frontiers in rehabilitation sciences · 2025Article
- Old Age and Frailty in Deceased Organ Transplantation and Allocation-A Plea for Geriatric Assessment and Prehabilitation.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Outcomes of patients with COVID-19 on kidney replacement therapy: a comparison among modalities in England.Clinical kidney journal · 2021Article
- Physical Inactivity: A Modifiable Risk Factor for Morbidity and Mortality in Kidney Transplantation.Journal of personalized medicine · 2021Review
- Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding how frailty affects patients listed for transplantation has been identified as a priority research need. Frailty may be associated with a high risk of death or wait-list withdrawal, but this has not been evaluated in a large multicenter cohort of Canadian wait-listed patients.
objectiveThe primary objective is to evaluate whether frailty is associated with death or permanent withdrawal from the transplant wait list. Secondary objectives include assessing whether frailty is associated with hospitalization, quality of life, and the probability of being accepted to the wait list.
designProspective cohort study.
settingSeven sites with established renal transplant programs that evaluate patients for the kidney transplant wait list. PATIENTS: Individuals who are being considered for the kidney transplant wait list. MEASUREMENTS: We will assess frailty using the Fried Phenotype, a frailty index, the Short Physical Performance Battery, and the Clinical Frailty Scale at the time of listing for transplantation. We will also assess frailty at the time of referral to the wait list and annually after listing in a subgroup of patients.
methodsThe primary outcome of the composite of time to death or permanent wait-list withdrawal will be compared between patients who are frail and those who are not frail and will account for the competing risks of deceased and live donor transplantation. Secondary outcomes will include number of hospitalizations and length of stay, and in a subset, changes in frailty severity over time, change in quality of life, and the probability of being listed. Recruitment of 1165 patients will provide >80% power to identify a relative hazard of ≥1.7 comparing patients who are frail to those who are not frail for the primary outcome (2-sided α = .05), whereas a more conservative recruitment target of 624 patients will provide >80% power to identify a relative hazard of ≥2.0.
resultsThrough December 2019, 665 assessments of frailty (inclusive of those for the primary outcome and all secondary outcomes including repeated measures) have been completed. LIMITATIONS: There may be variation across sites in the processes of referral and listing for transplantation that will require consideration in the analysis and results.
conclusionsThis study will provide a detailed understanding of the association between frailty and outcomes for wait-listed patients. Understanding this association is necessary before routinely measuring frailty as part of the wait-list eligibility assessment and prior to ascertaining the need for interventions that may modify frailty.
trial registrationNot applicable as this is a protocol for a prospective observational study.
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