ArticleBiological trace element research2021
Toxic Impacts of Amorphous Silica Nanoparticles on Liver and Kidney of Male Adult Rats: an In Vivo Study.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Nanomaterial-Based Precision Drug Delivery for Advanced Nephrology Therapy: A Systematic Review.International journal of nanomedicine · 2026Pooled it
- Article
- Silica Nanoparticles Induced Epithelial-Mesenchymal Transition in BEAS-2B Cells via ER Stress and SIRT1/HSF1/HSPs Signaling Pathway.Journal of xenobiotics · 2025Article
- Toxicity study of silica nanoparticles following 94-day repeated oral administration in Sprague Dawley rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Size-Dependent Cytotoxicity and Multi-Omic Changes Induced by Amorphous Silicon Nanoparticles in HepG2 Cells.Toxics · 2025Article
- Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology.Particle and fibre toxicology · 2025Article
- Therapeutic potential of green-synthesized silver nanoparticles: Combating biofilms of multidrug-resistantVeterinary world · 2024Article
- Health burden of sugarcane burning on agricultural workers and nearby communities.Inhalation toxicology · 2024Review
- Biocompatibility and sub-chronic toxicity studies of phlorotannin/polycaprolactone coated trachea tube for advancing medical device applications.Scientific reports · 2024Article
- Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments.Particle and fibre toxicology · 2023Article
- Article
- Toxicity and Impact of Silica Nanoparticles on the Configuration of Gut Microbiota in Immunodeficient Mice.Microorganisms · 2023Article
- Article
- Life Cycle Assessment of Functionalized Bionanocompounds with Ice Nucleation Protein for Freezing Applications.Polymers · 2023Article
- Survival, growth, behavior, hematology and serum biochemistry of mice under different concentrations of orally administered amorphous silica nanoparticle.Toxicology reports · 2023Article
- Insecticidal efficacy of nanomaterials used to control mosquito, Culex quinquefasciatus Say, 1823 with special reference to their hepatotoxicity in rats.Bioscience reports · 2022Article
- Protective and Therapeutic Efficacy of Hesperidin versus Cisplatin against Ehrlich Ascites Carcinoma-Induced Renal Damage in Mice.Pharmaceuticals (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The toxic effects of the amorphous silica nanoparticles have not been thoroughly studied. Moreover, the majority of the in vivo investigations were performed using an inhalation exposure method. The current study aimed to explore the potential toxic effects of silica nanoparticles (SiNPs) after the treatment of adult male rats with two different concentrations (500 and 1000 ppm) via drinking water for 28 days. The genotoxicity, antioxidant status, and liver and kidney functions were assessed. Besides, histopathological and immunohistochemical evaluations were performed. The results showed a significant elevation in the malondialdehyde (MDA) level concurrent with a reduction in total reduced glutathione (GSH) concentration and catalase activity in the 1000-ppm SiNP-exposed rats as well as increase in ALT and AST activity confirmed by various histopathological alterations detected in liver. Also, in the 1000-ppm SiNP-exposed animals, there was an elevation in urea and creatinine levels confirmed by histopathological alterations detected in kidneys. Immunohistochemical findings in both liver and kidneys indicated strong expression of caspase-3 in the 1000-ppm SiNP-treated rats compared with the control and 500-ppm SiNP-treated groups. Such findings indicated that the 1000-ppm SiNPs exerted severe hepato-renal toxic impacts when compared with the control and 500-ppm SiNP-exposed rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.