Evidence map›Paper›PMID 32964541›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2021

Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank.

Zahra Raisi-Estabragh, Luca Biasiolli, Jackie Cooper, Nay Aung, Kenneth Fung, José M Paiva, Mihir M Sanghvi, Ross J Thomson, Elizabeth Curtis, Julien Paccou and 11 more

Open access · hybridAbstract read
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In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  13. Calcaneal quantitative ultrasound is associated with all-cause and cardiovascular disease mortality independent of hip bone mineral density.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Zahra Raisi-EstabraghWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.ORCID 0000-0002-7757-5465
Luca BiasiolliDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.ORCID 0000-0002-0452-8756
Jackie CooperWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.
Nay AungWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.
Kenneth FungWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.
José M PaivaWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.ORCID 0000-0002-9369-6785
Mihir M SanghviWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.
Ross J ThomsonDepartment of Cardiology, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK.ORCID 0000-0002-8229-8060
Elizabeth CurtisMedical Research Council (MRC) Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Julien PaccouRheumatology Department, Lille University Hospital, CHU Lille, MABlab ULR 4490, 59037 Lille, France.ORCID 0000-0001-6599-8623
Jennifer J RaynerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Konrad WerysDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Henrike PuchtaDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Katharine E ThomasDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Aaron M LeeWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.
Stefan K PiechnikDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Stefan NeubauerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Patricia B MunroeWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.ORCID 0000-0002-4176-2947
Cyrus CooperMedical Research Council (MRC) Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID 0000-0003-3510-0709
Steffen E PetersenWilliam Harvey Research Institute, National Institute for Health Research (NIHR) Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK.
Nicholas C HarveyMedical Research Council (MRC) Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID 0000-0002-8194-2512
National Health Service · GBNational Institute for Health Research · GBQueen Mary University of London · GBMRC Lifecourse Epidemiology Unit · GBRoyal Free London NHS Foundation Trust · GBUniversité de Lille · FR

Funding

Arthritis Research UKBritish Heart Foundation FS/17/81/33318British Heart Foundation PG/14/89/31194British Heart Foundation PG/15/74/31747Department of Health 10/33/04Department of Health EP/P001009/1Medical Research Council 4050502589Medical Research Council G0400491Medical Research Council MC_PC_17228Medical Research Council MC_PC_21003Medical Research Council MC_QA137853Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Versus Arthritis 17702Wellcome Trust 203553Wellcome Trust 203553/Z/16/ZWellcome Trust 203553/Z/Z
6 · The paper itself

Abstract

Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial stiffness index [ASI]); and (iii) incident myocardial infarction and IHD mortality in the UK Biobank cohort. We considered the potential mediating effect of a range of blood biomarkers and cardiometabolic morbidities and evaluated differential relationships by sex, menopause status, smoking, diabetes, and obesity. Furthermore, we considered whether associations with arterial compliance explained association of SOS with ischemic cardiovascular outcomes. Higher SOS was associated with lower arterial compliance by both ASI and AD for both men and women. The relationship was most consistent with ASI, likely relating to larger sample size available for this variable (n = 159,542 versus n = 18,229). There was no clear evidence of differential relationship by menopause, smoking, diabetes, or body mass index (BMI). Blood biomarkers appeared important in mediating the association for both men and women, but with different directions of effect and did not fully explain the observed effects. In fully adjusted models, higher SOS was associated with significantly lower IHD mortality in men, but less robustly in women. The association of SOS with ASI did not explain this observation. In conclusion, our findings support a positive association between bone and vascular health with consistent patterns of association in men and women. The underlying mechanisms are complex and appear to vary by sex. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Indexed as

Vascular StiffnessBiological Specimen BanksFemaleHumansMaleRisk FactorsUltrasonographyUnited KingdomARTERIAL STIFFNESSCARDIOVASCULAR DISEASEEPIDEMIOLOGYISCHEMIC HEART DISEASEOSTEOPOROSIS

Identifiers

PMID32964541
PMCPMC7613252
OpenAlexW3087863701

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.