Evidence map›Paper›PMID 32972536›Full record

ReviewJournal of the American College of Cardiology2020

Cardiovascular Biomarkers and Imaging in Older Adults: JACC Council Perspectives.

Daniel E Forman, James A de Lemos, Leslee J Shaw, David B Reuben, Radmila Lyubarova, Eric D Peterson, John A Spertus, Susan Zieman, Marcel E Salive, Michael W Rich and 1 more

Abstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Integrating Senescence and Oxidative Stress in Cardiac Disease.International journal of molecular sciences · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Proceedings of the Alzheimer's Diagnosis in Older Adults With Chronic Conditions Network Inaugural Annual Conference.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel E FormanSection of Geriatric Cardiology, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania; Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. Electronic address: formand@pitt.edu.
James A de LemosDivision of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Leslee J ShawDepartment of Medicine and Radiology, Weill Cornell Medical College, New York, New York.
David B ReubenDivision of Geriatrics, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, California.
Radmila LyubarovaDivision of Cardiology, Department of Medicine, Albany Medical College, Albany, New York.
Eric D PetersonDuke University Medical Center, Durham, North Carolina.
John A SpertusSaint Luke's Mid America Heart Institute, the University of Missouri-Kansas City, Kansas City, Missouri.
Susan ZiemanDivision of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, Maryland.
Marcel E SaliveDivision of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, Maryland.
Michael W RichWashington University School of Medicine, St. Louis, Missouri.
Geriatric Cardiology Section Leadership Council

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Molecular Transducers of Physical Activity Consortium Adult Clinical CenterU01AR071130 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUSI, NICOLAS, RASMUSSEN, BLAKE B · 2017 to 2024
$17.7M
Modified Application of Cardiac Rehabilitation (CR) for Older Adults (MACRO)R01AG060499 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORMAN, DANIEL E. · 2018 to 2022
$5.0M
Nitrite therapy to improve mitochondrial energetics and physical activity in older adultsR01AG058883 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORMAN, DANIEL E. · 2019 to 2021
$2.0M
Integration of Geriatrics Principles into the Care of Older Adults with CardiovasU13AG047008 · NIA · AMERICAN COLLEGE OF CARDIOLOGY · PI RICH, MICHAEL W · 2014 to 2018
$210k
NIAMS NIH HHS U01 AR071130NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG058883NIA NIH HHS R01 AG060499NIA NIH HHS U13 AG047008
6 · The paper itself

Abstract

Whereas the burgeoning population of older adults is intrinsically vulnerable to cardiovascular disease, the utility of many management precepts that were validated in younger adults is often unclear. Whereas biomarker- and imaging-based tests are a major part of cardiovascular disease care, basic assumptions about their use and efficacy cannot be simply extrapolated to many older adults. Biology, physiology, and body composition change with aging, with important influences on cardiovascular disease testing procedures and their interpretation. Furthermore, clinical priorities of older adults are more heterogeneous, potentially undercutting the utility of testing data that are collected. The American College of Cardiology and the National Institutes on Aging, in collaboration with the American Geriatrics Society, convened, at the American College of Cardiology Heart House, a 2-day multidisciplinary workshop, "Diagnostic Testing in Older Adults with Cardiovascular Disease," to address these issues. This review summarizes key concepts, clinical limitations, and important opportunities for research.

Indexed as

Cardiac Imaging TechniquesAgedAgingBiomarkersExercise TestHumansBiomarkersagingbiomarkerscardiovascular testingimagingshared decision makingstress testing

Identifiers

PMID32972536
PMCPMC7540920

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.