Evidence map›Paper›PMID 32982113›Full record

ArticleWorld journal of gastroenterology2020

Acupuncture improved lipid metabolism by regulating intestinal absorption in mice.

Jia Han, Xin Guo, Xiang-Jin Meng, Jing Zhang, Reimon Yamaguchi, Yoshiharu Motoo, Sohsuke Yamada

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jia HanDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Xin GuoDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Xiang-Jin MengDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Jing ZhangDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Reimon YamaguchiDepartment of Dermatology, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Yoshiharu MotooDepartment of Oncology, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Sohsuke YamadaDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Kanazawa Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-alcoholic fatty liver disease (NAFLD), in which abnormal lipid metabolism plays an important role in disease progression, has become a pandemic. Abnormal lipid metabolism, for example an increased fat intake, has been thought to be an initial factor leading to NAFLD. The small intestine is the main site of dietary lipid absorption. A number of clinical trials have shown that acupuncture has positive effects in the regulation of lipid metabolism, which is closely associated with the progression of NAFLD. We therefore hypothesized that, acupuncture can improve the conditions of NAFLD by regulating intestinal absorption of lipid.

aimTo study the role of acupuncture treatment in the improvement of metabolic syndrome secondary to NAFLD by mouse model.

methods8-wk-old male C57BL/6J mice were fed a methionine- and choline-deficient diet for 3 wk. Then, all mice were separated randomly into acupoints group (AG) or non-acupoints group (NG) with high fat diet feeding. Needling treatment was performed at Zu san li, Guan yuan and Yong quan acupoints as acupuncture treatment to AG mice while non-acupoints place to NG mice. Finally, mice were anesthetized with an injection of ketamine-medetomidine and euthanized by exsanguination.

resultsAn apparent improvement of obesity was found in AG mice after acupuncture treatment. In AG mice, the body weight was much lower (22.6 ± 1.2 g

conclusionThese results indicate that acupuncture at Zu san li, Guan yuan and Yong quan suppressed lipid absorption by downregulating the expression of apolipoproteins in the small intestine.

Indexed as

Acupuncture TherapyNon-alcoholic Fatty Liver DiseaseAcupuncture PointsAnimalsDiet, High-FatIntestinal AbsorptionLipid MetabolismLiverMaleMiceMice, Inbred C57BLAcupunctureApolipoproteinsLipid metabolismNon-alcoholic fatty liver diseaseSmall intestine

Identifiers

PMID32982113
PMCPMC7495030
OpenAlexW3084098958

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.