ReviewCellular and molecular life sciences : CMLS2021
Molecular and neurocircuitry mechanisms of social avoidance.
Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- Early life adversity disrupts adult social reward motivation.bioRxiv : the preprint server for biology · 2026Article
- The sources of suicidal ambivalence: favorable and risk factors for suicidal ideation among higher vocational college freshmen-a large sample survey.BMC psychiatry · 2026Article
- The mediating role of physical exercise in the relationship between university students' interpersonal disturbance and conflict resolution strategies.Frontiers in psychology · 2026Article
- The temporal relationships between social motivation and social interactions in people with serious mental illness and recent homelessness.Journal of mental health (Abingdon, England) · 2025Article
- Chronic Unpredictable Stress Impairs Social Behaviour in Adult Male Rats: Correlations with Dopamine and Serotonin Levels.Molecular neurobiology · 2025Article
- Influence of the HPA Axis on Anxiety-Related Processes: An RDoC Overview Considering Their Neural Correlates.Current psychiatry reports · 2025Review
- Intersect between brain mechanisms of conditioned threat, active avoidance, and reward.Communications psychology · 2025Review
- Future Directions in Anxiolytic Therapy: A Comprehensive Review of Novel Targets and Strategies.Current neurovascular research · 2025Review
- Study of tree shrew biology and models: A booming and prosperous field for biomedical research.Zoological research · 2024Review
- How Socially Avoidant Emerging Adults Process Social Feedback during Human-to-Human Interaction after Social Rejection: An Event-Related Potential Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- Graph theory-based analysis reveals neural anatomical network alterations in chronic post-traumatic stress disorder.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Exploring the Nexus between Moderate-to-Vigorous Physical Activity, Self-Disclosure, Social Anxiety, and Adolescent Social Avoidance: Insights from a Cross-Sectional Study in Central China.Children (Basel, Switzerland) · 2023Article
- Long-term effects of chronic stress models in adult mice.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Social avoidance behavior modulates motivational responses to social reward-threat conflict signals: A preliminary fMRI study.Cognitive, affective & behavioral neuroscience · 2023Article
- The relation between college students' neuroticism and loneliness: The chain mediating roles of self-efficacy, social avoidance and distress.Frontiers in psychology · 2023Article
- Dopamine, Psychosis, and Symptom Fluctuation: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Review
- Assessing Prevalence and Unique Risk Factors of Suicidal Ideation among First-Year University Students in China Using a Unique Multidimensional University Personality Inventor.International journal of environmental research and public health · 2022Article
- Stress vulnerability shapes disruption of motor cortical neuroplasticity.Translational psychiatry · 2022Article
- Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits.International journal of molecular sciences · 2022Article
- Social factors and the neurobiology of pathogen avoidance.Biology letters · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans and animals live in social relationships shaped by actions of approach and avoidance. Both are crucial for normal physical and mental development, survival, and well-being. Active withdrawal from social interaction is often induced by the perception of threat or unpleasant social experience and relies on adaptive mechanisms within neuronal networks associated with social behavior. In case of confrontation with overly strong or persistent stressors and/or dispositions of the affected individual, maladaptive processes in the neuronal circuitries and its associated transmitters and modulators lead to pathological social avoidance. This review focuses on active, fear-driven social avoidance, affected circuits within the mesocorticolimbic system and associated regions and a selection of molecular modulators that promise translational potential. A comprehensive review of human research in this field is followed by a reflection on animal studies that offer a broader and often more detailed range of analytical methodologies. Finally, we take a critical look at challenges that could be addressed in future translational research on fear-driven social avoidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.