Evidence map›Paper›PMID 32998951›Full record

ArticleGenetics2020

Suppressors of mRNA Decapping Defects Restore Growth Without Major Effects on mRNA Decay Rates or Abundance.

Minseon Kim, Ambro van Hoof

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Eukaryotic mRNA Decapping Activation.Frontiers in genetics · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Minseon KimMicrobiology and Molecular Genetics Department, University of Texas Health Science Center at Houston, Houston, Texas 77030.ORCID 0000-0001-5299-0008
Ambro van HoofMicrobiology and Molecular Genetics Department, University of Texas Health Science Center at Houston, Houston, Texas 77030 ambro.van.hoof@uth.tmc.edu.ORCID 0000-0002-7800-9764
The University of Texas Health Science Center at Houston · US

Funding

RNA decay and processing activities of the RNA exosomeR01GM099790 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VAN HOOF, AMBRO · 2012 to 2020
$2.6M
NIGMS NIH HHS R01 GM099790
6 · The paper itself

Abstract

Faithful degradation of mRNAs is a critical step in gene expression, and eukaryotes share a major conserved mRNA decay pathway. In this major pathway, the two rate-determining steps in mRNA degradation are the initial gradual removal of the poly(A) tail, followed by removal of the cap structure. Removal of the cap structure is carried out by the decapping enzyme, containing the Dcp2 catalytic subunit. Although the mechanism and regulation of mRNA decay is well understood, the consequences of defects in mRNA degradation are less clear. Dcp2 has been reported as either essential or nonessential. Here, we clarify that Dcp2 is not absolutely required for spore germination and extremely slow growth, but in practical terms it is impossible to continuously culture

Indexed as

RNA Stabilitybeta KaryopherinsEndoribonucleasesLoss of Function MutationRNA, Transfer, LeuSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpores, Fungalbeta KaryopherinsDCP2 protein, S cerevisiaeEndoribonucleasesKap123 protein, S cerevisiaeRNA, Transfer, LeuSaccharomyces cerevisiae ProteinsDCP2decappingKAP123mRNA decaytL(GAG)G

Identifiers

PMID32998951
PMCPMC7768250
OpenAlexW3091531797

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.