Evidence map›Paper›PMID 32999841›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC.

Ibrahim Javed, Zhenzhen Zhang, Jozef Adamcik, Nicholas Andrikopoulos, Yuhuan Li, Daniel E Otzen, Sijie Lin, Raffaele Mezzenga, Thomas P Davis, Feng Ding and 1 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 82 citations in OpenAlex.

  1. The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
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  4. Article
  5. Article
  6. Exploring the role of infectious pathogens in Alzheimer's disease neuroinflammation.Frontiers in cellular and infection microbiology · 2026
    Review
  7. Review
  8. The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Review
  10. The Evolution of Functional Amyloids and Their Impact on Host-Microbe Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Experimental methods for studying amyloid cross-interactions.Protein science : a publication of the Protein Society · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Ibrahim JavedAustralian Institute for Bioengineering and Nanotechnology University of Queensland Brisbane QLD 4072 Australia.
Zhenzhen ZhangDepartment of Physics and Astronomy Clemson University Clemson SC 29634 USA.
Jozef AdamcikFood & Soft Materials Department of Health Science & Technology ETH Zurich Schmelzbergstrasse 9, LFO, E23 Zurich 8092 Switzerland.
Nicholas AndrikopoulosARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville VIC 3052 Australia.
Yuhuan LiARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville VIC 3052 Australia.
Daniel E OtzenInterdisciplinary Nanoscience Center (iNANO) University of Aarhus Aarhus C Aarhus 8000 Denmark.
Sijie LinCollege of Environmental Science and Engineering Biomedical Multidisciplinary Innovation Research Institute Shanghai East Hospital Shanghai Institute of Pollution Control and Ecological Security Tongji University 1239 Siping Road Shanghai 200092 China.
Raffaele MezzengaFood & Soft Materials Department of Health Science & Technology ETH Zurich Schmelzbergstrasse 9, LFO, E23 Zurich 8092 Switzerland.
Thomas P DavisAustralian Institute for Bioengineering and Nanotechnology University of Queensland Brisbane QLD 4072 Australia.ORCID https://orcid.org/0000-0003-2581-4986
Feng DingDepartment of Physics and Astronomy Clemson University Clemson SC 29634 USA.
Pu Chun KeARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville VIC 3052 Australia.
Clemson University · USETH Zurich · CHMolecular Research Institute · USThe University of Queensland · AUAarhus University · DKShanghai East Hospital · CNSun Yat-sen University · CN

Funding

Inhibition of Human Islet Amyloid Polypeptide AggregationR35GM119691 · NIGMS · CLEMSON UNIVERSITY · PI DING, FENG · 2016 to 2020
$1.9M
NIGMS NIH HHS R35 GM119691
6 · The paper itself

Abstract

The gut-brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (A

Indexed as

amyloid diseasesamyloidosisbrain health cross seedinggut–brain axisneurotoxicity

Identifiers

PMID32999841
PMCPMC7509637
OpenAlexW3043085161

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.