Evidence map›Paper›PMID 33005632›Full record

ReviewFrontiers in cardiovascular medicine2020

Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging.

Kenichiro Otsuka, Martin Villiger, Seemantini K Nadkarni, Brett E Bouma

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. NIRS-IVUS Assessment of OCT-Derived Healed Coronary Plaques.Journal of atherosclerosis and thrombosis · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kenichiro OtsukaWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Martin VilligerWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Seemantini K NadkarniWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Brett E BoumaWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Harvard University · USMassachusetts General Hospital · US

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Jacqueline Namati · 2012 to 2026
$22.4M
Intracoronary imaging of plaque collagen in patientsR01HL119065 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BOUMA, BRETT E, NADKARNI, SEEMANTINI K · 2014 to 2017
$3.2M
NHLBI NIH HHS R01 HL119065NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) visualize the coronary artery wall and plaque morphology in great detail. The advent of these high-resolution intracoronary imaging modalities has propelled our understanding of coronary atherosclerosis and provided enhanced guidance for percutaneous coronary intervention. Yet, the lack of contrast between distinct tissue types and plaque compositions impedes further elucidation of the complex mechanisms that contribute to acute coronary syndrome (ACS) and hinders the prospective identification of plaques susceptible to rupture. Intravascular polarimetry with polarization-sensitive OFDI measures polarization properties of the coronary arterial wall using conventional intravascular imaging catheters. The quantitative polarization metrics display notable image contrast between several relevant coronary plaque microstructures that are difficult to identify with conventional OCT and OFDI. Tissues rich in collagen and smooth muscle cells exhibit birefringence, while lipid and macrophages cause depolarization. In this review, we describe the basic principles of intravascular polarimetry, discuss the interpretation of the polarization signatures, and outline promising avenues for future research and clinical implications.

Indexed as

atherosclerosiscollagendrug-eluting stentmacrophageneoatherosclerosisoptical coherence tomographypolarimetrysmooth muscle cells

Identifiers

PMID33005632
PMCPMC7485575
OpenAlexW3081703659

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.